{"id":"11c2eef4c408","type":"article","url":"https://hartvaat.nl/2016/01/01/centrale-versus-perifere-bloeddruk-en-doelorgaanschade-systematische-review-en-m/","title":"Centrale versus perifere bloeddruk en doelorgaanschade: systematische review en meta-analyse","title_en":"Association of Central Versus Brachial Blood Pressure With Target-Organ Damage: Systematic Review and Meta-Analysis.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts","internist"],"tags":["bloeddrukbehandeling","vrouwen"],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.115.06066","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.115.06066","authors":["Anastasios Kollias","Styliani Lagou","Maria Elena Zeniodi","Nadia Boubouchairopoulou","George S Stergiou"],"significance":6,"published":"2016-01-01","source_date":"2016-01-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/wat-is-hypertensie/","https://hartvaat.nl/kennis/farmacologie/betablokkers-farmacologie/"],"congress":"","summary_en":"This systematic review and meta-analysis compared the association of central versus brachial blood pressure with preclinical target organ damage, providing evidence that central pressure may be a more accurate marker of hemodynamic stress on vital organs.","created":"2026-07-03T10:25:51Z","updated":"2026-07-03T18:38:20Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Systematische review en meta-analyse die het verband onderzocht tussen centrale en perifere bloeddruk en preklinische doelorgaanschade. Centrale bloeddruk lijkt de hemodynamische belasting op doelorganen nauwkeuriger te weerspiegelen dan brachiaal gemeten bloeddruk.","abstract_original":"Accumulating evidence suggests that central blood pressure (BP) may reflect the hemodynamic stress on target organs more accurately than brachial BP. A systematic review assessing the relationship of central versus brachial BP with preclinical target-organ damage was performed. Meta-analysis of cross-sectional data showed that central compared with brachial systolic BP was more closely associated with (1) left ventricular mass index (12 studies, n=6431; weighted age [SD], 49.9 [13.1] years; 51% hypertensives): pooled correlation coefficients r=0.30; 95% confidence interval (CI), 0.23-0.37 versus r=0.26; 95% CI, 0.19-0.33, respectively; P<0.01 for difference; (2) carotid intima-media thickness (7 studies, n=6136; weighted age, 55.6 [13.2] years; 48% hypertensives): r=0.27; 95% CI, 0.19-0.34 versus r=0.23; 95% CI, 0.16-0.30, respectively; P<0.01 for difference; (3) pulse-wave velocity (14 studies, n=3699; weighted age, 53.9 [13.3] years; 53% hypertensives): r=0.42; 95% CI, 0.37-0.47 versus r=0.39; 95% CI, 0.33-0.45, respectively; P<0.01 for difference. Four studies assessing urine albumin excretion (n=3718; weighted age, 56.4 [5] years; 69% hypertensives) reported similar correlations (P=not significant) with central (r=0.22; 95% CI, 0.14-0.29) and brachial systolic BP (r=0.22; 95% CI, 0.12-0.32). Similar findings were observed for central compared with brachial pulse pressure in terms of relationship with target-organ damage. Metaregression analyses did not reveal any significant effect of age. In conclusion, central compared with brachial BP seems to be more strongly associated with most of the investigated indices of preclinical organ damage."}