# Katheterablatie herstelt verlaagde plasma miR-409-3p en miR-432 bij atriumfibrilleren

*geplaatst 2016-01-01 · Atriumfibrilleren · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · doi 10.1093/europace/euu366 · https://hartvaat.nl/2016/01/01/katheterablatie-herstelt-verlaagde-plasma-mir-409-3p-en-mir-432-bij-atriumfibril/*

Deze studie onderzocht veranderingen in plasma-microRNA-expressie bij patiënten met atriumfibrilleren vóór en na katheterablatie. De resultaten tonen aan dat ablatie specifieke miRNA-niveaus kan herstellen, wat nieuwe inzichten biedt in de pathofysiologie van AF en potentiële biomarkers voor therapierespons.

## English: Catheter ablation restores decreased plasma miR-409-3p and miR-432 in atrial fibrillation patients.

This study identified specific plasma microRNA expression changes in atrial fibrillation patients before and after catheter ablation. Ablation restored decreased miR-409-3p and miR-432 levels, offering potential biomarkers for monitoring therapeutic response.

## Abstract (original, from the publication)

AIMS: Despite numerous studies identifying specific microRNA (miRNA) expression profiles associated with atrial fibrillation (AF), changes in plasma miRNA expression in pre- and post-operative AF patients who have received catheter ablation, remain poorly characterized. This study aimed to reveal disease-related biomarkers by detecting plasma miRNA expression in AF patients, and examining the levels of AF-specific miRNAs in patients after catheter ablation, in order to help gauge therapeutic effects and assess prognosis. METHODS AND RESULTS: A total of 100 Han Chinese patients with AF who had received catheter ablation, and 100 healthy individuals, were sequentially recruited to the study. Atrial fibrillation-specific plasma miRNAs were detected by Solexa sequencing and quantitative reverse transcription polymerase chain reaction. The expression levels of AF-specific miRNAs were also investigated in 40 post-operative patients (24-48 h) and 20 patients followed up (58.52 ± 36.00 days) after catheter ablation, to explore changes in miRNA expression. The expressions of miR-409-3p and miR-432 in the plasma of AF patients were lower than healthy individuals. In binary logistic regression analyses, reduced miR-409-3p and miR-432 levels were independently associated with AF (95% confidence interval: 1.02-2.22 and 1.09-2.43, P = 0.040 and 0.018, respectively). The levels of miR-409-3p and miR-432 showed no significant difference between post-operative patients and healthy individuals (P = 0.411 and 0.681, respectively), or between followed-up patients and healthy individuals (P = 0.720 and 0.073, respectively). CONCLUSION: We suggest that plasma miR-409-3p and miR-432 are potential markers of AF, and catheter ablation restores their decreased levels in AF patients.

Auteurs: Tian Liu, Shilong Zhong, Fang Rao, Yumei Xue, Zhoucuo Qi, Shulin Wu

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Bron: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, https://doi.org/10.1093/europace/euu366. Bijgewerkt 2026-07-03T13:25:13Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.