{"id":"8b898930dfbf","type":"article","url":"https://hartvaat.nl/2016/01/07/preoperatief-statinegebruik-en-cardiovasculaire-complicaties-bij-niet-cardiale-c/","title":"Preoperatief statinegebruik en cardiovasculaire complicaties bij niet-cardiale chirurgie: de VISION-studie","title_en":"Association between pre-operative statin use and major cardiovascular complications among patients undergoing non-cardiac surgery: the VISION study.","category":"cholesterol","category_label":"Cholesterol","professions":["apotheker","cardioloog","internist"],"tags":["farmaco-economie","obesitas","ouderen","secundaire-preventie","select-trial"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehv456","source_url":"https://doi.org/10.1093/eurheartj/ehv456","authors":["Otavio Berwanger","Yannick Le Manach","Erica Aranha Suzumura","Bruce Biccard","Sadeesh K Srinathan","Wojciech Szczeklik","Jose A Espirito Santo","Eliana Santucci","Alexandre B Cavalcanti","R Andrew Archbold","P J Devereaux"],"significance":6,"published":"2016-01-07","source_date":"2016-01-07","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lipidenmedicatie-bij-ckd/","https://hartvaat.nl/kennis/lipiden/lpa-meten-wanneer-waarom/"],"congress":"","summary_en":"This international prospective cohort study examined the association between preoperative statin use and major cardiovascular complications within 30 days of non-cardiac surgery, informing perioperative medication management.","created":"2026-07-03T10:25:52Z","updated":"2026-07-03T13:25:14Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Internationale prospectieve cohortstudie bij patiënten ≥45 jaar die niet-cardiale chirurgie ondergingen. Onderzocht het effect van preoperatieve statinetherapie op cardiovasculaire events in de eerste 30 dagen na operatie.","abstract_original":"AIMS: The aim of this study was to assess the effects of pre-operative statin therapy on cardiovascular events in the first 30-days after non-cardiac surgery. METHODS AND RESULTS: We conducted an international, prospective, cohort study of patients who were ≥45 years having in-patient non-cardiac surgery. We estimated the probability of receiving statins pre-operatively using a multivariable logistic model and conducted a propensity score analysis to correct for confounding. A total of 15 478 patients were recruited at 12 centres in eight countries from August 2007 to January 2011. The matched population consisted of 2845 patients (18.4%) treated with a statin and 4492 (29.0%) controls. The pre-operative use of statins was associated with lower risk of the primary outcome, a composite of all-cause mortality, myocardial injury after non-cardiac surgery (MINS), or stroke at 30 days [relative risk (RR), 0.83; 95% confidence interval (CI), 0.73-0.95; P = 0.007]. Statins were also associated with a significant lower risk of all-cause mortality (RR, 0.58; 95% CI, 0.40-0.83; P = 0.003), cardiovascular mortality (RR, 0.42; 95% CI, 0.23-0.76; P = 0.004), and MINS (RR, 0.86; 95% CI, 0.73-0.98; P = 0.02). There were no statistically significant differences in the risk of myocardial infarction or stroke. CONCLUSION: Among patients undergoing non-cardiac surgery, pre-operative statin therapy was independently associated with a lower risk of cardiovascular outcomes at 30 days. These results require confirmation in a large randomized trial. CLINICAL TRIAL REGISTRATION: Clinical Trials.gov NCT00512109."}