{"id":"7bd6498752d2","type":"article","url":"https://hartvaat.nl/2016/01/26/relatieve-wanddikte-en-risico-op-ventriculaire-tachyaritmieen-bij-linkerkamerdis/","title":"Relatieve wanddikte en risico op ventriculaire tachyaritmieën bij linkerkamerdisfunctie","title_en":"Relative Wall Thickness and the Risk for Ventricular Tachyarrhythmias in Patients With Left Ventricular Dysfunction.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":["bradycardie","cardiale-resynchronisatie","katheterablatie","laminopathie","pulmonaalvenenisolatie","rechterventrikelfalen","supraventriculaire-tachycardie","ventriculaire-tachycardie","ventrikelfibrilleren"],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2015.10.076","source_url":"https://doi.org/10.1016/j.jacc.2015.10.076","authors":["Yitschak Biton","Ilan Goldenberg","Valentina Kutyifa","Jayson R Baman","Scott Solomon","Arthur J Moss","Barbara Szepietowska","Scott McNitt","Bronislava Polonsky","Wojciech Zareba","Alon Barsheshet"],"significance":5,"published":"2016-01-26","source_date":"2016-01-26","image":"","kennis":["https://hartvaat.nl/kennis/diagnostiek/transthoracale-echocardiografie/"],"congress":"","summary_en":"This study showed that relative wall thickness, a measure of left ventricular geometry, predicts ventricular tachyarrhythmias in patients with LV dysfunction, potentially improving risk stratification for ICD therapy.","created":"2026-07-03T10:25:54Z","updated":"2026-07-03T13:25:16Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie naar relatieve wanddikte (RWT) als maat voor linkerkamergeometrie en voorspeller van ventriculaire tachyaritmieën bij patiënten met LV-disfunctie. RWT kan een aanvullende risicomarker zijn bovenop de ejectiefractie.","abstract_original":"BACKGROUND: Relative wall thickness (RWT), defined as 2 times posterior wall thickness divided by the left ventricular (LV) diastolic diameter, is a measure of LV geometry and may be a marker for adverse events in patients with LV dysfunction. OBJECTIVES: The aim of this study was to investigate the relationship between RWT and the risk for ventricular tachyarrhythmia (VA) in patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study. METHODS: The study population comprised 1,260 patients with mild heart failure and left bundle branch block. RESULTS: In a multivariable model, RWT was the most powerful echocardiographic measure for estimating the risk of VAs compared with commonly used echocardiographic variables. Patients with low RWT (<0.24) had 83% (p < 0.001) increased risk for VA and 68% (p < 0.001) increase in VA risk or death (VA/death) compared with patients with higher RWT values. Each 0.01-unit decrease in RWT was associated with 12% (p < 0.001) and 10% (p < 0.001) increases in the risk of VA and VA/death, respectively. Treatment with cardiac resynchronization therapy with defibrillator (CRT-D; CRT with implantable cardioverter-defibrillator) was associated with a greater increase in RWT compared with implantable cardioverter-defibrillator at 12 months (4.6 ± 6.8% vs. 1.5 ± 2.7%; p < 0.001), and every 10% increase in RWT in CRT-D patients was associated with 34% (p = 0.027) and 36% (p = 0.009) reductions in the risk of subsequent VA and VA/death, respectively. CONCLUSIONS: In patients with mild heart failure and left bundle branch block, decreased RWT was associated with an increase in the risk of VA and VA/death. CRT-D therapy was associated with a favorable increase in RWT and reduction in risk of VA and VA/death. (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy [MADIT-CRT]; NCT00180271)."}