{"id":"4d854f1f2056","type":"article","url":"https://hartvaat.nl/2016/02/09/peergroepinterventie-voor-cardiovasculaire-risicofactoren-de-fifty-fifty-trial/","title":"Peergroepinterventie voor cardiovasculaire risicofactoren: de Fifty-Fifty-trial","title_en":"A Comprehensive Lifestyle Peer Group-Based Intervention on Cardiovascular Risk Factors: The Randomized Controlled Fifty-Fifty Program.","category":"preventie","category_label":"Preventie","professions":["cardioloog","huisarts"],"tags":["acuut-hartfalen","aperitif-trial","biomarkers-cardiovasculair","diabetes-en-hart","diabetes-type-2","farmaco-economie","fidelity","figaro-dkd","gepersonaliseerde-geneeskunde","hartrevalidatie","inflammatie","menopauze","obesitas","ouderen","pathfinder-trial","richtlijnen-esc","roken","secundaire-preventie","select-trial","slaapapneu","soul-trial","summit-trial"],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2015.10.033","source_url":"https://doi.org/10.1016/j.jacc.2015.10.033","authors":["Emilia Gómez-Pardo","Juan Miguel Fernández-Alvira","Marta Vilanova","Domingo Haro","Ramona Martínez","Isabel Carvajal","Vanesa Carral","Carla Rodríguez","Mercedes de Miguel","Patricia Bodega","Gloria Santos-Beneit","Jose Luis Peñalvo","Iñaki Marina","Napoleón Pérez-Farinós","Marian Dal Re","Carmen Villar","Teresa Robledo","Rajesh Vedanthan","Sameer Bansilal","Valentin Fuster"],"significance":6,"published":"2016-02-09","source_date":"2016-02-09","image":"","kennis":["https://hartvaat.nl/kennis/preventie/levenslang-cardiovasculair-risico/","https://hartvaat.nl/kennis/lipiden/lp-a-verhoogd/"],"congress":"","summary_en":"This randomized trial demonstrated that a comprehensive lifestyle intervention incorporating peer support achieves significant improvements in cardiovascular risk factors, supporting group-based behavioral change programs for cardiovascular prevention.","created":"2026-07-03T10:25:57Z","updated":"2026-07-03T13:25:18Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Gerandomiseerde trial die een uitgebreide leefstijlinterventie met peersupport onderzocht voor modificatie van cardiovasculaire risicofactoren. Onderzoekt de effectiviteit van groepsgebaseerde preventiestrategieën.","abstract_original":"BACKGROUND: Cardiovascular diseases stem from modifiable risk factors. Peer support is a proven strategy for many chronic illnesses. Randomized trials assessing the efficacy of this strategy for global cardiovascular risk factor modification are lacking. OBJECTIVES: This study assessed the hypothesis that a peer group strategy would help improve healthy behaviors in individuals with cardiovascular risk factors. METHODS: A total of 543 adults 25 to 50 years of age with at least 1 risk factor were recruited; risk factors included hypertension (20%), overweight (82%), smoking (31%), and physical inactivity (81%). Subjects were randomized 1:1 to a peer group-based intervention group (IG) or a self-management control group (CG) for 12 months. Peer-elected leaders moderated monthly meetings involving role-play, brainstorming, and activities to address emotions, diet, and exercise. The primary outcome was mean change in a composite score related to blood pressure, exercise, weight, alimentation, and tobacco (Fuster-BEWAT score, 0 to 15). Multilevel models with municipality as a cluster variable were applied to assess differences between groups. RESULTS: Participants' mean age was 42 ± 6 years, 71% were female, and they had a mean baseline Fuster-BEWAT score of 8.42 ± 2.35. After 1 year, the mean scores were significantly higher in the IG (n = 277) than in the CG (n = 266) (IG mean score: 8.84; 95% confidence interval (CI): 8.37 to 9.32; CG mean score: 8.17; 95% CI: 7.55 to 8.79; p = 0.02). The increase in the overall score was significantly larger in the IG compared with the CG (difference: 0.75; 95% CI: 0.32 to 1.18; p = 0.02). The mean improvement in the individual components was uniformly greater in the IG, with a significant difference for the tobacco component. CONCLUSIONS: The peer group intervention had beneficial effects on cardiovascular risk factors, with significant improvements in the overall score and specifically on tobacco cessation. A follow-up assessment will be performed 1 year after the final assessment reported here to determine long-term sustainability of the improvements associated with peer group intervention. (Peer-Group-Based Intervention Program [Fifty-Fifty]; NCT02367963)."}