{"id":"1d8d66a1cb20","type":"article","url":"https://hartvaat.nl/2016/03/15/voorspelling-van-persisterende-lv-disfunctie-na-myocardinfarct-de-predicts-studi/","title":"Voorspelling van persisterende LV-disfunctie na myocardinfarct: de PREDICTS-studie","title_en":"Predicting Persistent Left Ventricular Dysfunction Following Myocardial Infarction: The PREDICTS Study.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["laminopathie","myocardinfarct","ventrikelfibrilleren"],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2015.12.042","source_url":"https://doi.org/10.1016/j.jacc.2015.12.042","authors":["Gabriel C Brooks","Byron K Lee","Rajni Rao","Feng Lin","Daniel P Morin","Steven L Zweibel","Alfred E Buxton","Mark J Pletcher","Eric Vittinghoff","Jeffrey E Olgin"],"significance":6,"published":"2016-03-15","source_date":"2016-03-15","image":"","kennis":["https://hartvaat.nl/kennis/kleplijden/aortastenose/","https://hartvaat.nl/kennis/coronairlijden/esc-richtlijn-chronisch-coronairlijden-2024/"],"congress":"","summary_en":"The PREDICTS study identified clinical and imaging predictors of persistent severe LV dysfunction after myocardial infarction, informing the timing and selection of patients for ICD implantation based on early post-MI assessment.","created":"2026-07-03T10:25:59Z","updated":"2026-07-03T13:25:21Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die voorspellers identificeerde van persisterende ernstige LV-systolische disfunctie na myocardinfarct — een klasse I indicatie voor ICD-implantatie. Klinisch relevant voor optimale timing van devicetherapie.","abstract_original":"BACKGROUND: Persistent severe left ventricular (LV) systolic dysfunction after myocardial infarction (MI) is associated with increased mortality and is a class I indication for implantation of a cardioverter-defibrillator. OBJECTIVES: This study developed models and assessed independent predictors of LV recovery to >35% and ≥50% after 90-day follow-up in patients presenting with acute MI and severe LV dysfunction. METHODS: Our multicenter prospective observational study enrolled participants with ejection fraction (EF) of ≤35% at the time of MI (n = 231). Predictors for EF recovery to >35% and ≥50% were identified after multivariate modeling and validated in a separate cohort (n = 236). RESULTS: In the PREDICTS (PREDiction of ICd Treatment Study) study, 43% of patients had persistent EF ≤35%, 31% had an EF of 36% to 49%, and 26% had an EF ≥50%. The model that best predicted recovery of EF to >35% included EF at presentation, length of stay, prior MI, lateral wall motion abnormality at presentation, and peak troponin. The model that best predicted recovery of EF to ≥50% included EF at presentation, peak troponin, prior MI, and presentation with ventricular fibrillation or cardiac arrest. After predictors were transformed into point scores, the lowest point scores predicted a 9% and 4% probability of EF recovery to >35% and ≥50%, respectively, whereas profiles with the highest point scores predicted an 87% and 49% probability of EF recovery to >35% and ≥50%, respectively. CONCLUSIONS: In patients with severe systolic dysfunction following acute MI with an EF ≤35%, 57% had EF recovery to >35%. A model using clinical variables present at the time of MI can help predict EF recovery."}