{"id":"2e245d45cb8b","type":"article","url":"https://hartvaat.nl/2016/03/22/genetische-risicoscore-en-ldl-cholesterolbehandeling-bij-coronairlijden/","title":"Genetische risicoscore en LDL-cholesterolbehandeling bij coronairlijden","title_en":"Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial).","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts","internist"],"tags":["biomarkers-cardiovasculair","diabetes-type-2","dyslipidemie","ezetimibe","familiaire-hypercholesterolemie","familiaire-hypercholesterolemie-screening","gepersonaliseerde-geneeskunde","hdl-cholesterol","laminopathie","ldl-cholesterol","lipide-aferese","lipidenverlaging","lipoproteïne-a","lipoproteïne-a-therapeutisch-doel","pcsk9-remmers","statines"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.115.020109","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.115.020109","authors":["Iftikhar J Kullo","Hayan Jouni","Erin E Austin","Sherry-Ann Brown","Teresa M Kruisselbrink","Iyad N Isseh","Raad A Haddad","Tariq S Marroush","Khader Shameer","Janet E Olson","Ulrich Broeckel","Robert C Green","Daniel J Schaid","Victor M Montori","Kent R Bailey"],"significance":6,"published":"2016-03-22","source_date":"2016-03-22","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lpa-meten-wanneer-waarom/","https://hartvaat.nl/kennis/lipiden/dyslipidemie-overzicht/"],"congress":"","summary_en":"This study tested whether incorporating a genetic risk score for coronary heart disease into clinical risk assessment changes health behaviors or LDL cholesterol levels, exploring the behavioral impact of genomic risk information.","created":"2026-07-03T10:26:00Z","updated":"2026-07-03T13:25:22Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die onderzocht of kennis van een genetische risicoscore voor coronairlijden effect heeft op gezondheidsuitkomsten, met name LDL-cholesterolniveaus en behandelbeleid. Pionierend onderzoek naar klinische toepassing van polygene risicoscores.","abstract_original":"BACKGROUND: Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS: Participants (n=203, 45-65 years of age, at intermediate risk for CHD, and not on statins) were randomly assigned to receive their 10-year probability of CHD based either on a conventional risk score (CRS) or CRS + GRS ((+)GRS). Participants in the (+)GRS group were stratified as having high or average/low GRS. Risk was disclosed by a genetic counselor followed by shared decision making regarding statin therapy with a physician. We compared the primary end point of LDL-C levels at 6 months and assessed whether any differences were attributable to changes in dietary fat intake, physical activity levels, or statin use. Participants (mean age, 59.4±5 years; 48% men; mean 10-year CHD risk, 8.5±4.1%) were allocated to receive either CRS (n=100) or (+)GRS (n=103). At the end of the study period, the (+)GRS group had a lower LDL-C than the CRS group (96.5±32.7 versus 105.9±33.3 mg/dL; P=0.04). Participants with high GRS had lower LDL-C levels (92.3±32.9 mg/dL) than CRS participants (P=0.02) but not participants with low GRS (100.9±32.2 mg/dL; P=0.18). Statins were initiated more often in the (+)GRS group than in the CRS group (39% versus 22%, P<0.01). No significant differences in dietary fat intake and physical activity levels were noted. CONCLUSIONS: Disclosure of CHD risk estimates that incorporated genetic risk information led to lower LDL-C levels than disclosure of CHD risk based on conventional risk factors alone. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01936675."}