{"id":"d512bc438edc","type":"article","url":"https://hartvaat.nl/2016/07/19/visit-to-visit-ldl-cholesterolvariabiliteit-en-cognitieve-functie/","title":"Visit-to-visit LDL-cholesterolvariabiliteit en cognitieve functie","title_en":"Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","internist"],"tags":["bempedoïnezuur","cetp-remmers","dyslipidemie","ezetimibe","familiaire-hypercholesterolemie","familiaire-hypercholesterolemie-screening","hdl-cholesterol","ldl-cholesterol","lipide-aferese","lipidenverlaging","niet-statine-therapie","statines"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.115.020627","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.115.020627","authors":["Roelof A J Smit","Stella Trompet","Behnam Sabayan","Saskia le Cessie","Jeroen van der Grond","Mark A van Buchem","Anton J M de Craen","J Wouter Jukema"],"significance":6,"published":"2016-07-19","source_date":"2016-07-19","image":"","kennis":[],"congress":"","summary_en":"This study showed that higher visit-to-visit variability in LDL cholesterol is associated with lower cognitive performance and increased white matter hyperintensities, linking lipid instability to neurocognitive outcomes.","created":"2026-07-03T10:26:14Z","updated":"2026-07-03T13:25:34Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat hogere visit-to-visit variabiliteit in LDL-cholesterol geassocieerd is met lagere cognitieve prestaties en kleiner hersenvolume. Pleit voor stabiele cholesterolcontrole boven fluctuerende niveaus.","abstract_original":"BACKGROUND: Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. METHODS: We investigated the association between LDL-C variability and 4 cognitive domains at month 30 in 4428 participants of PROSPER (PROspective Study of Pravastatin in the Elderly at Risk). Additionally, we assessed the association of LDL-C variability with neuroimaging outcomes in a subset of 535 participants. LDL-C variability was defined as the intraindividual standard deviation over 4 postbaseline LDL-C measurements, and all analyses were adjusted for mean LDL-C levels and cardiovascular risk factors. RESULTS: Higher LDL-C variability was associated with lower cognitive function in both the placebo and pravastatin treatment arms. Associations were present for selective attention (P=0.017 and P=0.11, respectively), processing speed (P=0.20 and P=0.029), and memory (immediate recall, P=0.002 and P=0.006; delayed recall, P=0.001 and P≤0.001). Furthermore, higher LDL-C variability was associated with lower cerebral blood flow in both trial arms (P=0.031 and P=0.050) and with greater white matter hyperintensity load in the pravastatin arm (P=0.046). No evidence was found for interaction between LDL-C variability and pravastatin treatment for both cognitive and magnetic resonance imaging outcomes. CONCLUSIONS: We found that higher visit-to-visit variability in LDL-C, independently of mean LDL-C levels and statin treatment, is associated with lower cognitive performance, lower cerebral blood flow, and greater white matter hyperintensity load."}