# Polyfenolrijk dieet en cardiovasculair risico: gerandomiseerde trial

*geplaatst 2016-09-01 · Hypertensie · Heart (British Cardiac Society) · doi 10.1136/heartjnl-2015-309218 · https://hartvaat.nl/2016/09/01/polyfenolrijk-dieet-en-cardiovasculair-risico-gerandomiseerde-trial/*

Gerandomiseerde trial die het gunstige effect van een polyfenolrijk dieet op cardiovasculaire risicofactoren aantoonde. Onderbouwt het belang van voedingspatronen voor cardiovasculaire preventie.

## English: Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial.

This randomized trial demonstrated that a polyphenol-rich diet reduces cardiovascular risk factors including blood pressure and inflammatory markers, supporting dietary polyphenol intake as a modifiable component of cardiovascular prevention.

## Abstract (original, from the publication)

OBJECTIVES: There is previous epidemiological evidence that intake of polyphenol-rich foods has been associated with reduced cardiovascular disease risk. We aimed to investigate the effect of increasing dietary polyphenol intake on microvascular function in hypertensive participants. METHODS: All participants completed a 4-week run-in phase, consuming <2 portions of fruit and vegetables (F&V) daily and avoiding berries and dark chocolate. Subjects were then randomised to continue with the low-polyphenol diet for 8 weeks or to consume a high-polyphenol diet of six portions F&V (including one portion of berries/day and 50 g of dark chocolate). Endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside) vasodilator responses were assessed by venous occlusion plethysmography. Compliance with the intervention was measured using food diaries and biochemical markers. RESULTS: Final analysis of the primary endpoint was conducted on 92 participants. Between-group comparison of change in maximum % response to ACh revealed a significant improvement in the high-polyphenol group (p=0.02). There was a significantly larger increase in vitamin C, carotenoids and epicatechin in the high-polyphenol group (between-group difference p<0.001; p<0.001; p=0.008, respectively). CONCLUSIONS: This study has shown that increasing the polyphenol content of the diet via consumption of F&V, berries and dark chocolate results in a significant improvement in an established marker of cardiovascular risk in hypertensive participants. TRIAL REGISTRATION NUMBER: NCT01319786.

Auteurs: Rebecca L Noad, Ciara Rooney, Damian McCall, Ian S Young, David McCance, Michelle C McKinley, Jayne V Woodside, Pascal P McKeown

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Bron: Heart (British Cardiac Society), https://doi.org/10.1136/heartjnl-2015-309218. Bijgewerkt 2026-07-03T13:25:37Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.