{"id":"21a338a40026","type":"article","url":"https://hartvaat.nl/2016/11/01/chips-trial-is-ernstige-hypertensie-in-de-zwangerschap-meer-dan-alleen-verhoogde/","title":"CHIPS-trial: is ernstige hypertensie in de zwangerschap meer dan alleen verhoogde bloeddruk?","title_en":"The CHIPS Randomized Controlled Trial (Control of Hypertension in Pregnancy Study): Is Severe Hypertension Just an Elevated Blood Pressure?","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts"],"tags":["bloeddrukbehandeling"],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.116.07862","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.116.07862","authors":["Laura A Magee","Peter von Dadelszen","Joel Singer","Terry Lee","Evelyne Rey","Susan Ross","Elizabeth Asztalos","Kellie E Murphy","Jennifer Menzies","Johanna Sanchez","Amiram Gafni","Michael Helewa","Eileen Hutton","Gideon Koren","Shoo K Lee","Alexander G Logan","Wessel Ganzevoort","Ross Welch","Jim G Thornton","Jean-Marie Moutquin"],"significance":6,"published":"2016-11-01","source_date":"2016-11-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/esc-richtlijn-hypertensie-2024/","https://hartvaat.nl/kennis/hypertensie/classificatie-bloeddruk-esc-2024/"],"congress":"","summary_en":"This CHIPS analysis examined whether severe hypertension during pregnancy represents a distinct clinical phenotype with different treatment responses, providing nuanced guidance for managing the most dangerous pregnancy-related blood pressure elevations.","created":"2026-07-03T10:26:23Z","updated":"2026-07-03T18:38:28Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"CHIPS-analyse die onderzocht of ernstige hypertensie in de zwangerschap een ander klinisch fenotype vertegenwoordigt met specifieke risico's bovenop de bloeddrukhoogte.","abstract_original":"UNLABELLED: To determine whether clinical outcomes differed by occurrence of severe hypertension in the international CHIPS trial (Control of Hypertension in Pregnancy Study), adjusting for the interventions of \"less tight\" (target diastolic blood pressure [dBP] 100 mm Hg) versus \"tight\" control (target dBP 85 mm Hg). In this post-hoc analysis of CHIPS data from 987 women with nonsevere nonproteinuric preexisting or gestational hypertension, mixed effects logistic regression was used to compare the following outcomes according to occurrence of severe hypertension, adjusting for allocated group and the influence of baseline factors: CHIPS primary (perinatal loss or high-level neonatal care for >48 hours) and secondary outcomes (serious maternal complications), birth weight <10th percentile, preeclampsia, delivery at <34 or <37 weeks, platelets <100×109/L, elevated liver enzymes with symptoms, maternal length of stay ≥10 days, and maternal readmission before 6 weeks postpartum. Three hundred and thirty-four (34.1%) women in CHIPS developed severe hypertension that was associated with all outcomes examined except for maternal readmission (P=0.20): CHIPS primary outcome, birth weight <10th percentile, preeclampsia, preterm delivery, elevated liver enzymes (all P<0.001), platelets <100×109/L (P=0.006), and prolonged hospital stay (P=0.03). The association between severe hypertension and serious maternal complications was seen only in less tight control (P=0.02). Adjustment for preeclampsia (464, 47.3%) did not negate the relationship between severe hypertension and the CHIPS primary outcome (P<0.001), birth weight <10th percentile (P=0.005), delivery at <37 (P<0.001) or <34 weeks (P<0.001), or elevated liver enzymes with symptoms (P=0.02). Severe hypertension is a risk marker for adverse maternal and perinatal outcomes, independent of BP control or preeclampsia co-occurrence. CLINICAL TRIAL REGISTRATION: URL: http://pre-empt.cfri.ca/. Unique identifier: ISRCTN 71416914. URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01192412."}