{"id":"292482b16c77","type":"article","url":"https://hartvaat.nl/2016/12/13/csl112-gereconstitueerd-apoliproteine-a-i-na-acuut-mi-veiligheid-en-verdraagbaar/","title":"CSL112: gereconstitueerd apoliproteïne A-I na acuut MI — veiligheid en verdraagbaarheid","title_en":"Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I).","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog"],"tags":["bempedoïnezuur","cetp-remmers","hdl-cholesterol","lipide-aferese","lipoproteïne-a","lipoproteïne-a-therapeutisch-doel"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.116.025687","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.116.025687","authors":["C Michael Gibson","Serge Korjian","Pierluigi Tricoci","Yazan Daaboul","Megan Yee","Purva Jain","John H Alexander","P Gabriel Steg","A Michael Lincoff","John J P Kastelein","Roxana Mehran","Denise M D'Andrea","Lawrence I Deckelbaum","Bela Merkely","Maciej Zarebinski","Ton Oude Ophuis","Robert A Harrington"],"significance":6,"published":"2016-12-13","source_date":"2016-12-13","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/hdl-functie-en-reverse-cholesterol/"],"congress":"","summary_en":"This study established the safety and tolerability of CSL112, a reconstituted plasma-derived apoA-I infusion, after acute MI, providing the foundation for the subsequent AEGIS cardiovascular outcomes trial.","created":"2026-07-03T10:26:27Z","updated":"2026-07-03T13:25:47Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie naar de veiligheid en verdraagbaarheid van CSL112, een infuseerbaar plasma-afgeleid apoliproteïne A-I, na acuut myocardinfarct. Onderzoekt reverse cholesteroltransport als therapeutisch concept.","abstract_original":"BACKGROUND: Human or recombinant apolipoprotein A-I (apoA-I) has been shown to increase high-density lipoprotein-mediated cholesterol efflux capacity and to regress atherosclerotic disease in animal and clinical studies. CSL112 is an infusible, plasma-derived apoA-I that has been studied in normal subjects or those with stable coronary artery disease. This study aimed to characterize the safety, tolerability, pharmacokinetics, and pharmacodynamics of CSL112 in patients with a recent acute myocardial infarction. METHODS: The AEGIS-I trial (Apo-I Event Reducing in Ischemic Syndromes I) was a multicenter, randomized, double-blind, placebo-controlled, dose-ranging phase 2b trial. Patients with myocardial infarction were stratified by renal function and randomized 1:1:1 to CSL112 (2 g apoA-I per dose) and high-dose CSL112 (6 g apoA-I per dose), or placebo for 4 consecutive weekly infusions. Coprimary safety end points were occurrence of either a hepatic safety event (an increase in alanine transaminase >3 times the upper limit of normal or an increase in total bilirubin >2 times the upper limit of normal) or a renal safety event (an increase in serum creatinine >1.5 times the baseline value or a new requirement for renal replacement therapy). RESULTS: A total of 1258 patients were randomized, and 91.2% received all 4 infusions. The difference in incidence rates for an increase in alanine transaminase or total bilirubin between both CSL112 arms and placebo was within the protocol-defined noninferiority margin of 4%. Similarly, the difference in incidence rates for an increase in serum creatinine or a new requirement for renal replacement therapy was within the protocol-defined noninferiority margin of 5%. CSL112 was associated with increases in apoA-I and ex vivo cholesterol efflux similar to that achieved in patients with stable coronary artery disease. In regard to the secondary efficacy end point, the risk for the composite of major adverse cardiovascular events among the groups was similar. CONCLUSIONS: Among patients with acute myocardial infarction, 4 weekly infusions of CSL112 are feasible, well tolerated, and not associated with any significant alterations in liver or kidney function or other safety concern. The ability of CSL112 to acutely enhance cholesterol efflux was confirmed. The potential benefit of CSL112 to reduce major adverse cardiovascular events needs to be assessed in an adequately powered phase 3 trial. CLINICAL TRIAL REGISTRATION: URL: https://clinicaltrials.gov. Unique identifier: NCT02108262."}