{"id":"0d03d4f65fff","type":"article","url":"https://hartvaat.nl/2017/01/01/percutane-linker-hartoorsluiting-munchen-consensusdocument-over-definities-en-ei/","title":"Percutane linker-hartoorsluiting: München-consensusdocument over definities en eindpunten","title_en":"Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints, and data collection requirements for clinical studies.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog"],"tags":[],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euw141","source_url":"https://doi.org/10.1093/europace/euw141","authors":["Apostolos Tzikas","David R Holmes","Sameer Gafoor","Carlos E Ruiz","Carina Blomström-Lundqvist","Hans-Christoph Diener","Riccardo Cappato","Saibal Kar","Randal J Lee","Robert A Byrne","Reda Ibrahim","Dhanunjaya Lakkireddy","Osama I Soliman","Michael Nabauer","Steffen Schneider","Johannes Brachmann","Jeffrey L Saver","Klaus Tiemann","Horst Sievert","A John Camm","Thorsten Lewalter"],"significance":6,"published":"2017-01-01","source_date":"2017-01-01","image":"","kennis":[],"congress":"","summary_en":"This Munich consensus document standardized definitions, endpoints, and data collection requirements for percutaneous LAA occlusion research, addressing the heterogeneity that had complicated comparison of LAAO studies.","created":"2026-07-03T10:26:29Z","updated":"2026-07-03T13:25:48Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Consensusdocument dat definities, eindpunten en dataverzamelingsvereisten standaardiseert voor onderzoek naar percutane linker-hartoorsluiting. Raamwerk voor vergelijkbaarheid van toekomstige studies.","abstract_original":"The increasing interest in left atrial appendage occlusion (LAAO) for ischaemic stroke prevention in atrial fibrillation (AF) fuels the need for more clinical data on the safety and effectiveness of this therapy. Besides an assessment of the effectiveness of the therapy in specific patients groups, comparisons with pharmacological stroke prophylaxis, surgical approaches, and other device-based therapies are warranted. This paper documents the consensus reached among clinical experts in relevant disciplines from Europe and North America, European cardiology professional societies, and representatives from the medical device industry regarding definitions for parameters and endpoints to be assessed in clinical studies. Adherence to these definitions is proposed in order to achieve a consistent approach across clinical studies on LAAO among the involved stakeholders and various clinical disciplines and thereby facilitate continued evaluation of therapeutic strategies available."}