{"id":"3ce1dc0a3d0d","type":"article","url":"https://hartvaat.nl/2017/02/01/reductie-van-onnodige-ventriculaire-pacing-en-klinische-uitkomsten-bij-behouden-/","title":"Reductie van onnodige ventriculaire pacing en klinische uitkomsten bij behouden LV-functie","title_en":"Reduction in unnecessary ventricular pacing fails to affect hard clinical outcomes in patients with preserved left ventricular function: a meta-analysis.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog"],"tags":["acuut-hartfalen","aficamten","bradycardie","cardiale-resynchronisatie","hypertrofische-cardiomyopathie","laminopathie","linkerbundeltakpacing","lvad","rechterventrikelfalen","supraventriculaire-tachycardie","ventriculaire-tachycardie","ventrikelfibrilleren"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euw221","source_url":"https://doi.org/10.1093/europace/euw221","authors":["Mohammed Shurrab","Jeff S Healey","Saleem Haj-Yahia","Anna Kaoutskaia","Giuseppe Boriani","Aldo Carrizo","Gianluca Botto","David Newman","Luigi Padeletti","Stuart J Connolly","Eugene Crystal"],"significance":5,"published":"2017-02-01","source_date":"2017-02-01","image":"","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/af-bij-ouderen/"],"congress":"","summary_en":"This meta-analysis showed that reduction in unnecessary right ventricular pacing through device algorithms does not improve hard clinical endpoints in patients with preserved LV function, questioning the clinical impact of pacing minimization.","created":"2026-07-03T10:26:32Z","updated":"2026-07-03T18:38:30Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat reductie van onnodige rechterkamerpacing niet leidt tot verbetering van harde klinische eindpunten bij patiënten met behouden LV-functie.","abstract_original":"AIMS: Several pacing modalities across multiple manufacturers have been introduced to minimize unnecessary right ventricular pacing. We conducted a meta-analysis to assess whether ventricular pacing reduction modalities (VPRM) influence hard clinical outcomes in comparison to standard dual-chamber pacing (DDD). METHODS AND RESULTS: An electronic search was performed using Cochrane Central Register, PubMed, Embase, and Scopus. Only randomized controlled trials (RCT) were included in this analysis. Outcomes of interest included: frequency of ventricular pacing (VP), incident persistent/permanent atrial fibrillation (PerAF), all-cause hospitalization and all-cause mortality. Odds ratios (OR) were reported for dichotomous variables. Seven RCTs involving 4119 adult patients were identified. Ventricular pacing reduction modalities were employed in 2069 patients: (MVP, Medtronic Inc.) in 1423 and (SafeR, Sorin CRM, Clamart) in 646 patients. Baseline demographics and clinical characteristics were similar between VPRM and DDD groups. The mean follow-up period was 2.5 ± 0.9 years. Ventricular pacing reduction modalities showed uniform reduction in VP in comparison to DDD groups among all individual studies. The incidence of PerAF was similar between both groups {8 vs. 10%, OR 0.84 [95% confidence interval (CI) 0.57; 1.24], P = 0.38}. Ventricular pacing reduction modalities showed no significant differences in comparison to DDD for all-cause hospitalization or all-cause mortality [9 vs. 11%, OR 0.82 (95% CI 0.65; 1.03), P= 0.09; 6 vs. 6%, OR 0.97 (95% CI 0.74; 1.28), P = 0.84, respectively]. CONCLUSION: Novel VPRM measures effectively reduce VP in comparison to standard DDD. When actively programmed, VPRM did not improve clinical outcomes and were not superior to standard DDD programming in reducing incidence of PerAF, all-cause hospitalization, or all-cause mortality."}