{"id":"bee9e3a4ba8c","type":"article","url":"https://hartvaat.nl/2017/04/01/rol-van-adenosine-geleide-pvi-bij-katheterablatie-voor-af-meta-analyse/","title":"Rol van adenosine-geleide PVI bij katheterablatie voor AF: meta-analyse","title_en":"Role of adenosine-guided pulmonary vein isolation in patients undergoing catheter ablation for atrial fibrillation: a meta-analysis.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog"],"tags":["katheterablatie","pulmonaalvenenisolatie"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euw201","source_url":"https://doi.org/10.1093/europace/euw201","authors":["Yi-He Chen","Hui Lin","Cheng-Long Xie","Jian-Wen Hou","Yi-Gang Li"],"significance":5,"published":"2017-04-01","source_date":"2017-04-01","image":"","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/ritmecontrole-af/","https://hartvaat.nl/kennis/atriumfibrilleren/katheterablatie-af/"],"congress":"","summary_en":"This meta-analysis evaluated whether adenosine testing after initial pulmonary vein isolation adds value by unmasking dormant conduction, finding insufficient evidence to support routine adenosine challenge during AF ablation.","created":"2026-07-03T10:26:38Z","updated":"2026-07-03T13:25:56Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Meta-analyse naar de meerwaarde van adenosinetest na initiële pulmonaalvene-isolatie bij AF-ablatie. Onderzoekt of reconduction-detectie de langetermijnuitkomsten verbetert.","abstract_original":"AIMS: Adenosine had been reported to unmask dormant conduction and thus identify pulmonary vein at risk of reconnection. However, the role of adjunctive adenosine infusion after pulmonary vein isolation (PVI) on long-term arrhythmia-free survival was still contentious. The purpose of the present meta-analysis was to assess the association of adenosine testing with long-term ablation success in patients with atrial fibrillation (AF) (i.e. freedom from AF recurrence). METHODS AND RESULTS: We systematically searched the electronic databases and finally included 10 studies, with 1771 patients undergoing adenosine-guided PVI and 1787 patients undergoing conventional PVI. In comparison to conventional PVI alone, adenosine-guided PVI improved the arrhythmia-free survival by 17% during a median follow-up of 12 months [relative risk (RR): 1.17; 95% confidence interval (CI): 1.07 to 1.27; P = 0.014]. Patients undergoing adenosine-guided PVI had similar fluoroscopy time to those who undergoing conventional PVI [weighted mean difference (WMD): 1.76; 95% CI: -5.66 to 9.17; P = 0.64], despite longer procedure time (WMD: 20.6; 95% CI: 0.70 to 40.50; P = 0.042). CONCLUSION: From the available data of clinical studies, adenosine-guided PVI was associated with an increased arrhythmia-free survival when compared with conventional PVI in patients undergoing catheter ablation for AF."}