{"id":"0e08bc1256cc","type":"article","url":"https://hartvaat.nl/2017/04/14/zuurstofverrijkte-lucht-en-inspanningsprestatie-bij-precapillaire-pulmonale-hype/","title":"Zuurstofverrijkte lucht en inspanningsprestatie bij precapillaire pulmonale hypertensie","title_en":"Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog"],"tags":["bloeddrukbehandeling","pulmonale-hypertensie"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehx099","source_url":"https://doi.org/10.1093/eurheartj/ehx099","authors":["Silvia Ulrich","Elisabeth D Hasler","Stéphanie Saxer","Michael Furian","Séverine Müller-Mottet","Stephan Keusch","Konrad E Bloch"],"significance":5,"published":"2017-04-14","source_date":"2017-04-14","image":"","kennis":[],"congress":"","summary_en":"This randomized trial tested whether breathing oxygen-enriched air improves exercise performance in patients with precapillary pulmonary hypertension, evaluating supplemental oxygen as an exercise tolerance intervention.","created":"2026-07-03T10:26:39Z","updated":"2026-07-03T18:38:32Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Gerandomiseerde dubbelblinde trial naar het effect van zuurstofverrijkte lucht op inspanningsprestatie bij patiënten met precapillaire pulmonale hypertensie.","abstract_original":"AIMS: The purpose of the current trial was to test the hypothesis that breathing oxygen-enriched air increases exercise performance of patients with pulmonary arterial or chronic thrombo-embolic pulmonary hypertension (PAH/CTEPH) and to investigate involved mechanisms. METHODS AND RESULTS: Twenty-two patients with PAH/CTEPH, eight women, means ± SD 61 ± 14 years, resting mPAP 35 ± 9mmHg, PaO2 ambient air >7.3 kPa, underwent four bicycle ergospirometries to exhaustion on different days, while breathing oxygen-enriched (FiO2 0.50, hyperoxia) or ambient air (FiO2 0.21, normoxia) using progressively increased or constant load protocols (with 75% maximal work rate under FiO2 0.21), according to a randomized, sham-controlled, single-blind, cross-over design. ECG, pulmonary gas-exchange, arterial blood gases, cerebral and quadriceps muscle tissue oxygenation (CTO and QMTO) by near-infrared spectroscopy were measured. In ramp exercise, maximal work rate increased from 113 ± 38 W with normoxia to 132 ± 48 W with hyperoxia, mean difference 19.7 (95% CI 10.5-28.9) W, P < 0.001. Constant load exercise endurance increased from 571 ± 443 to 1242 ± 514 s, mean difference 671 (95% CI 392-951) s, P < 0.001. At end-exercise with hyperoxia PaO2, CTO, QMTO, and PaCO2 were increased, and ventilatory equivalents for CO2 were reduced while the physiological dead space/tidal volume ratio remained unchanged. CONCLUSION: In patients with PAH/CTEPH, breathing oxygen-enriched air provides major increases in exercise performance. This is related to an improved arterial oxygenation that promotes oxygen availability in muscles and brain and to a reduction of the excessive ventilatory response to exercise thereby enhancing ventilatory efficiency. Patients with PAH/CTEPH may therefore benefit from oxygen therapy during daily physical activities and training. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01748474."}