# Vroeg invasief versus selectieve strategie bij NSTE-ACS: ICTUS-trial langetermijn

*geplaatst 2017-04-18 · Algemeen · Journal of the American College of Cardiology · doi 10.1016/j.jacc.2017.02.023 · https://hartvaat.nl/2017/04/18/vroeg-invasief-versus-selectieve-strategie-bij-nste-acs-ictus-trial-langetermijn/*

Langetermijnfollow-up van de ICTUS-trial die vroeg invasieve versus selectieve strategie vergeleek bij NSTE-ACS. Voegt toe aan het bewijs over optimale timing van interventie.

## English: Early Invasive Versus Selective Strategy for Non-ST-Segment Elevation Acute Coronary Syndrome: The ICTUS Trial.

Long-term ICTUS follow-up comparing early invasive with selective invasive strategy in NSTE-ACS showed no significant long-term difference in outcomes, contributing to the nuanced understanding of invasive timing in acute coronary syndromes.

## Abstract (original, from the publication)

BACKGROUND: The ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes) trial compared early invasive strategy with a selective invasive strategy in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and an elevated cardiac troponin T. No long-term benefit of an early invasive strategy was found at 1 and 5 years. OBJECTIVES: The aim of this study was to determine the 10-year clinical outcomes of an early invasive strategy versus a selective invasive strategy in patients with NSTE-ACS and an elevated cardiac troponin T. METHODS: The ICTUS trial was a multicenter, randomized controlled clinical trial that included 1,200 patients with NSTE-ACS and an elevated cardiac troponin T. Enrollment was from July 2001 to August 2003. We collected 10-year follow-up of death, myocardial infarction (MI), and revascularization through the Dutch population registry, patient phone calls, general practitioners, and hospital records. The primary outcome was the 10-year composite of death or spontaneous MI. Additional outcomes included the composite of death or MI, death, MI (spontaneous and procedure-related), and revascularization. RESULTS: Ten-year death or spontaneous MI was not statistically different between the 2 groups (33.8% vs. 29.0%, hazard ratio [HR]: 1.12; 95% confidence interval [CI]: 0.97 to 1.46; p = 0.11). Revascularization occurred in 82.6% of the early invasive group and 60.5% in the selective invasive group. There were no differences in additional outcomes, except for a higher rate of death or MI in the early invasive group compared with the rates for the selective invasive group (37.6% vs. 30.5%; HR: 1.30; 95% CI: 1.07 to 1.58; p = 0.009), driven by a higher rate of procedure-related MI in the early invasive group (6.5% vs. 2.4%; HR: 2.82; 95% CI: 1.53 to 5.20; p = 0.001). CONCLUSIONS: In patients with NSTE-ACS and elevated cardiac troponin T levels, an early invasive strategy has no benefit over a selective invasive strategy in reducing the 10-year composite outcome of death or spontaneous MI, and a selective invasive strategy may be a viable option in selected patients.

Auteurs: Niels P G Hoedemaker, Peter Damman, Pier Woudstra, Alexander Hirsch, Fons Windhausen, Jan G P Tijssen, Robbert J de Winter

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Bron: Journal of the American College of Cardiology, https://doi.org/10.1016/j.jacc.2017.02.023. Bijgewerkt 2026-07-03T13:25:58Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.