# Kwaliteit van leven na chirurgie of DES bij drienvaten- of hoofdstamlijden

*geplaatst 2017-04-25 · Algemeen · Journal of the American College of Cardiology · doi 10.1016/j.jacc.2017.02.031 · https://hartvaat.nl/2017/04/25/kwaliteit-van-leven-na-chirurgie-of-des-bij-drienvaten-of-hoofdstamlijden/*

Vergelijking van kwaliteit van leven na CABG versus DES bij patiënten met drievaten- of linker-hoofdstamcoronairlijden. Patiëntgerapporteerde uitkomsten naast harde eindpunten.

## English: Quality of Life After Surgery or DES in Patients With 3-Vessel or Left Main Disease.

This SYNTAX quality-of-life analysis compared patient-reported outcomes after CABG versus PCI with DES in three-vessel or left main disease, providing the symptom and functional perspective alongside hard clinical endpoints.

## Abstract (original, from the publication)

BACKGROUND: In the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial, patients with 3-vessel or left main coronary artery disease (CAD) had improved long-term outcomes with coronary artery bypass graft (CABG) surgery compared with percutaneous coronary intervention (PCI) with drug-eluting stents (DES), improvements driven mainly by differences in myocardial infarction and repeat revascularization. OBJECTIVES: This study compared the long-term quality-of-life benefits of DES-PCI versus CABG for patients with 3-vessel or left main CAD. METHODS: Between 2005 and 2007, the SYNTAX trial randomized 1,800 patients with 3-vessel or left main CAD to either CABG or DES-PCI. Health status was assessed at baseline and at 1, 6, 12, 36, and 60 months by using the Seattle Angina Questionnaire (SAQ) and the 36-Item Short Form Health Survey. RESULTS: At 5-year follow-up, CABG was superior to DES-PCI on several SAQ domains including angina frequency and physical function, as well as the role physical and role emotional scales of the 36-Item Short Form Health Survey. Subgroup analysis demonstrated a significant interaction between angiographic complexity (as assessed by the SYNTAX score) and angina relief (mean difference in the SAQ angina frequency score for CABG vs. PCI of -0.9, 3.3, and 3.9 points for low, intermediate, and high SYNTAX score patients, respectively; p = 0.048 for interaction). CONCLUSIONS: Among patients with 3-vessel or left main CAD, both CABG and DES-PCI were associated with substantial and sustained quality-of-life benefits over 5 years of follow-up. In general, CABG resulted in greater angina relief, although the absolute treatment benefit was small. Angina relief at 5 years was enhanced with CABG among patients with high SYNTAX scores, a finding reinforcing the recommendation that CABG should be strongly preferred for such patients. (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery [SYNTAX]; NCT00114972).

Auteurs: Mouin S Abdallah, Kaijun Wang, Elizabeth A Magnuson, Ruben L Osnabrugge, A Pieter Kappetein, Marie-Claude Morice, Friedrich A Mohr, Patrick W Serruys, David J Cohen

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Bron: Journal of the American College of Cardiology, https://doi.org/10.1016/j.jacc.2017.02.031. Bijgewerkt 2026-07-03T13:25:58Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.