# Zoutbuffering in de huid bij mensen: een nieuw mechanisme

*geplaatst 2017-11-01 · Hypertensie · Hypertension (Dallas, Tex. : 1979) · doi 10.1161/HYPERTENSIONAHA.117.10003 · https://hartvaat.nl/2017/11/01/zoutbuffering-in-de-huid-bij-mensen-een-nieuw-mechanisme/*

Studie die een nieuw mechanisme beschrijft voor zoutbuffering in de menselijke huid via natrium-opslag en VEGF-C. Verandert het begrip van zoutbalans en bloeddrukregulatie.

## English: Novel Mechanism for Buffering Dietary Salt in Humans: Effects of Salt Loading on Skin Sodium, Vascular Endothelial Growth Factor C, and Blood Pressure.

This study described a novel mechanism for dietary salt buffering in human skin, showing that sodium is stored in skin tissue and triggers VEGF-C-mediated lymphangiogenesis, fundamentally changing the understanding of sodium homeostasis.

## Abstract (original, from the publication)

High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that dietary salt loading results in dermal Na+ accumulation and lymphangiogenesis mediated by VEGF-C (vascular endothelial growth factor C), both attenuating the rise in BP. Our objective was to determine whether these mechanisms function in humans. We assessed skin electrolytes, BP, and plasma VEGF-C in 48 healthy participants randomized to placebo (70 mmol sodium/d) and slow sodium (200 mmol/d) for 7 days. Skin Na+ and K+ concentrations were measured in mg/g of wet tissue and expressed as the ratio Na+:K+ to correct for variability in sample hydration. Skin Na+:K+ increased between placebo and slow sodium phases (2.91±0.08 versus 3.12±0.09; P=0.01). In post hoc analysis, there was a suggestion of a sex-specific effect, with a significant increase in skin Na+:K+ in men (2.59±0.09 versus 2.88±0.12; P=0.008) but not women (3.23±0.10 versus 3.36±0.12; P=0.31). Women showed a significant increase in 24-hour mean BP with salt loading (93±1 versus 91±1 mm Hg; P<0.001) while men did not (96±2 versus 96±2 mm Hg; P=0.91). Skin Na+:K+ correlated with BP, stroke volume, and peripheral vascular resistance in men but not in women. No change was noted in plasma VEGF-C. These findings suggest that the skin may buffer dietary Na+, reducing the hemodynamic consequences of increased salt, and this may be influenced by sex.

Auteurs: Viknesh Selvarajah, Kaisa M Mäki-Petäjä, Liliana Pedro, Sylvaine F A Bruggraber, Keith Burling, Anna K Goodhart, Morris J Brown, Carmel M McEniery, Ian B Wilkinson

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Bron: Hypertension (Dallas, Tex. : 1979), https://doi.org/10.1161/HYPERTENSIONAHA.117.10003. Bijgewerkt 2026-07-03T13:26:15Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.