{"id":"4108ecd33b76","type":"article","url":"https://hartvaat.nl/2018/03/13/caloriearm-vegetarisch-versus-mediterraan-dieet-voor-gewicht-en-cv-profiel-cardi/","title":"Caloriearm vegetarisch versus mediterraan dieet voor gewicht en CV-profiel: CARDIVEG","title_en":"Low-Calorie Vegetarian Versus Mediterranean Diets for Reducing Body Weight and Improving Cardiovascular Risk Profile: CARDIVEG Study (Cardiovascular Prevention With Vegetarian Diet).","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts"],"tags":["obesitas"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.117.030088","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.117.030088","authors":["Francesco Sofi","Monica Dinu","Giuditta Pagliai","Francesca Cesari","Anna Maria Gori","Alice Sereni","Matteo Becatti","Claudia Fiorillo","Rossella Marcucci","Alessandro Casini"],"significance":5,"published":"2018-03-13","source_date":"2018-03-13","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lpa-meten-wanneer-waarom/","https://hartvaat.nl/kennis/preventie/cardiovasculair-risico-begrippen/"],"congress":"","summary_en":"The CARDIVEG crossover study showed that a low-calorie vegetarian diet and a Mediterranean diet produce comparable improvements in body weight and cardiovascular risk profiles, supporting both dietary patterns for cardiometabolic health.","created":"2026-07-03T10:27:11Z","updated":"2026-07-03T13:26:27Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"CARDIVEG-studie die een caloriearm vegetarisch dieet vergeleek met een mediterraan dieet op gewichtsverlies en cardiovasculair risicoprofiel.","abstract_original":"BACKGROUND: Only a few randomized dietary intervention studies that investigated the effects of lacto-ovo vegetarian diet (Vd) in clinically healthy omnivorous subjects are available. METHODS: We randomly assigned to overweight omnivores with a low-to-moderate cardiovascular risk profile a low-calorie Vd compared with a low-calorie Mediterranean diet (MD), each lasting 3 months, with a crossover design. The primary outcome was the difference in body weight, body mass index, and fat mass changes between the 2 groups. Secondary outcomes were differences in circulating cardiovascular disease risk parameters changes between the 2 groups. RESULTS: One hundred eighteen subjects (mean age: 51.1 years, females: 78%) were enrolled. The total participation rate at the end of the study was 84.7%. No differences between the 2 diets in body weight were observed, as reported by similar and significant reductions obtained by both Vd (-1.88 kg) and MD (-1.77 kg). Similar results were observed for body mass index and fat mass. In contrast, significant differences between the 2 interventions were obtained for low-density lipoprotein cholesterol, triglycerides, and vitamin B12 levels. The difference between the Vd and MD groups, in terms of end-of-diet values, was recorded at 9.10 mg/dL for low-density lipoprotein cholesterol (P=0.01), 12.70 mg/dL for triglycerides (P<0.01), and 32.32 pg/mL for vitamin B12 (P<0.01). Finally, no significant difference was found between Vd and MD interventions in oxidative stress markers and inflammatory cytokines, except for interleukin-17, which improved only in the MD group. Forty-six participants during the Vd period and 35 during the MD period reached the target values for ≥1 cardiovascular risk factor. CONCLUSIONS: Both Vd and MD were effective in reducing body weight, body mass index, and fat mass, with no significant differences between them. However, Vd was more effective in reducing low-density lipoprotein cholesterol levels, whereas MD led to a greater reduction in triglyceride levels. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02641834."}