{"id":"07a338aeca17","type":"article","url":"https://hartvaat.nl/2018/03/13/leefstijlinterventies-en-mobilisatie-van-vetstapeling-central-mri-gerandomiseerd/","title":"Leefstijlinterventies en mobilisatie van vetstapeling: CENTRAL MRI gerandomiseerde trial","title_en":"Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: CENTRAL Magnetic Resonance Imaging Randomized Controlled Trial.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","internist"],"tags":["stride-trial"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.117.030501","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.117.030501","authors":["Yftach Gepner","Ilan Shelef","Dan Schwarzfuchs","Hila Zelicha","Lilac Tene","Anat Yaskolka Meir","Gal Tsaban","Noa Cohen","Nitzan Bril","Michal Rein","Dana Serfaty","Shira Kenigsbuch","Oded Komy","Arik Wolak","Yoash Chassidim","Rachel Golan","Hila Avni-Hassid","Avital Bilitzky","Benjamin Sarusi","Eyal Goshen","Elad Shemesh","Yaakov Henkin","Michael Stumvoll","Matthias Blüher","Joachim Thiery","Uta Ceglarek","Assaf Rudich","Meir J Stampfer","Iris Shai"],"significance":6,"published":"2018-03-13","source_date":"2018-03-13","image":"","kennis":[],"congress":"","summary_en":"The CENTRAL MRI trial used magnetic resonance imaging to compare how different lifestyle interventions (Mediterranean diet, exercise, dietary polyphenols) differentially mobilize specific body fat depots, advancing precision nutrition for cardiovascular risk.","created":"2026-07-03T10:27:11Z","updated":"2026-07-03T13:26:27Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"CENTRAL MRI-trial die het effect van verschillende leefstijlinterventies op vetdepots onderzocht met MRI-beeldvorming. Gedetailleerd inzicht in vetredistributie.","abstract_original":"BACKGROUND: We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. METHODS: We performed an 18-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to isocaloric low-fat or Mediterranean/low-carbohydrate (MED/LC) diet+28 g walnuts/day with/without added moderate physical activity (PA; 80% aerobic; supervised/free gym membership). Overall primary outcome was body fat redistribution, and the main specific end point was visceral adipose tissue (VAT). We further followed the dynamics of different fat depots (deep and superficial subcutaneous, liver, pericardial, muscle, pancreas, and renal sinus) by magnetic resonance imaging. RESULTS: Of 278 participants (age, 48 years, 89% men, body mass index, 30.8 kg/m2), 86% completed the trial with good adherence. The low-fat group preferentially decreased reported fat intake (-21.0% versus -11.5% for the MED/LC; P<0.001), and the MED/LC group decreased reported carbohydrates intake (-39.5% versus -21.3% for the low-fat group; P<0.001). The PA+ groups significantly increased the metabolic equivalents per week versus the PA- groups (19.0 versus 2.1; P=0.009). Whereas final moderate weight loss was indifferent, exercise attenuated the waist circumference rebound with the greatest effect in the MED/LCPA+ group (P<0.05). VAT (-22%), intrahepatic (-29%), and intrapericardial (-11%) fats declines were higher than pancreatic and femur intermuscular fats (1% to 2%) loss. Independent of weight loss, PA+ with either diet had a significantly greater effect on decreasing VAT (mean of difference, -6.67cm2; 95% confidence interval, -14.8 to -0.45) compared with PA-. The MED/LC diet was superior to the low-fat diet in decreasing intrahepatic, intrapericardial, and pancreatic fats (P<0.05 for all). In contrast, renal sinus and femoral intermuscular fats were not differentially altered by lifestyle interventions but by weight loss per se. In multivariate models further adjusted for weight loss, losing VAT or intrahepatic fat was independently associated with improved lipid profile, losing deep subcutaneous adipose tissue with improved insulin sensitivity, and losing superficial subcutaneous adipose tissue remained neutral except for an association with decreased leptin. CONCLUSIONS: Moderate weight loss alone inadequately reflects the significant lifestyle effects on atherogenic and diabetogenic fat depots. The MED/LC diet mobilizes specific ectopic fat depots, and exercise has an independent contribution to VAT loss. Fat depots exhibit diverse responsiveness and are differentially related to cardiometabolic markers. Distinct lifestyle protocols may uniquely induce fat mobilization from specific anatomic sites. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01530724."}