{"id":"caa112739231","type":"article","url":"https://hartvaat.nl/2018/04/03/oplaaddosis-atorvastatine-voor-pci-jama-gerandomiseerde-trial/","title":"Oplaaddosis atorvastatine vóór PCI: JAMA gerandomiseerde trial","title_en":"Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial.","category":"cholesterol","category_label":"Cholesterol","professions":["apotheker","cardioloog"],"tags":[],"journal":"JAMA","doi":"10.1001/jama.2018.2444","source_url":"https://doi.org/10.1001/jama.2018.2444","authors":["Otavio Berwanger","Eliana Vieira Santucci","Pedro Gabriel Melo de Barros E Silva","Isabella de Andrade Jesuíno","Lucas Petri Damiani","Lilian Mazza Barbosa","Renato Hideo Nakagawa Santos","Ligia Nasi Laranjeira","Flávia de Mattos Egydio","Juliana Aparecida Borges de Oliveira","Frederico Toledo Campo Dall Orto","Pedro Beraldo de Andrade","Igor Ribeiro de Castro Bienert","Carlos Eduardo Bosso","José Armando Mangione","Carisi Anne Polanczyk","Amanda Guerra de Moraes Rego Sousa","Renato Abdala Karam Kalil","Luciano de Moura Santos","Andrei Carvalho Sposito","Rafael Luiz Rech","Antônio Carlos Sobral Sousa","Felipe Baldissera","Bruno Ramos Nascimento","Roberto Rocha Corrêa Veiga Giraldez","Alexandre Biasi Cavalcanti","Sabrina Bernardez Pereira","Luiz Alberto Mattos","Luciana Vidal Armaganijan","Hélio Penna Guimarães","José Eduardo Moraes Rego Sousa","John Hunter Alexander","Christopher Bull Granger","Renato Delascio Lopes"],"significance":7,"published":"2018-04-03","source_date":"2018-04-03","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/omega3-vetzuren-cardiologie/","https://hartvaat.nl/kennis/lipiden/ezetimib/"],"congress":"","summary_en":"This JAMA trial showed that a loading dose of atorvastatin prior to planned PCI did not reduce major cardiovascular events in patients with ACS, arguing against routine statin loading before coronary intervention.","created":"2026-07-03T10:27:13Z","updated":"2026-07-03T13:26:28Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"JAMA gerandomiseerde trial naar het effect van een oplaaddosis atorvastatine vóór geplande PCI op cardiovasculaire events. Onderzocht periprocedurale statineloading.","abstract_original":"IMPORTANCE: The effects of loading doses of statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain. OBJECTIVE: To determine if periprocedural loading doses of atorvastatin decrease 30-day major adverse cardiovascular events (MACE) in patients with ACS and planned invasive management. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, double-blind, placebo-controlled, randomized clinical trial conducted at 53 sites in Brazil among 4191 patients with ACS evaluated with coronary angiography to proceed with a percutaneous coronary intervention (PCI) if anatomically feasible. Enrollment occurred between April 18, 2012, and October 6, 2017. Final follow-up for 30-day outcomes was on November 6, 2017. INTERVENTIONS: Patients were randomized to receive 2 loading doses of 80 mg of atorvastatin (n = 2087) or matching placebo (n = 2104) before and 24 hours after a planned PCI. All patients received 40 mg of atorvastatin for 30 days starting 24 hours after the second dose of study medication. MAIN OUTCOMES AND MEASURES: The primary outcome was MACE, defined as a composite of all-cause mortality, myocardial infarction, stroke, and unplanned coronary revascularization through 30 days. RESULTS: Among the 4191 patients (mean age, 61.8 [SD, 11.5] years; 1085 women [25.9%]) enrolled, 4163 (99.3%) completed 30-day follow-up. A total of 2710 (64.7%) underwent PCI, 333 (8%) underwent coronary artery bypass graft surgery, and 1144 (27.3%) had exclusively medical management. At 30 days, 130 patients in the atorvastatin group (6.2%) and 149 in the placebo group (7.1%) had a MACE (absolute difference, 0.85% [95% CI, -0.70% to 2.41%]; hazard ratio, 0.88; 95% CI, 0.69-1.11; P = .27). No cases of hepatic failure were reported; 3 cases of rhabdomyolysis were reported in the placebo group (0.1%) and 0 in the atorvastatin group. CONCLUSIONS AND RELEVANCE: Among patients with ACS and planned invasive management with PCI, periprocedural loading doses of atorvastatin did not reduce the rate of MACE at 30 days. These findings do not support the routine use of loading doses of atorvastatin among unselected patients with ACS and intended invasive management. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01448642."}