{"id":"6ab86a06faaf","type":"article","url":"https://hartvaat.nl/2018/05/01/bloeddruk-voor-conceptie-en-reproductieve-uitkomsten/","title":"Bloeddruk vóór conceptie en reproductieve uitkomsten","title_en":"Preconception Blood Pressure Levels and Reproductive Outcomes in a Prospective Cohort of Women Attempting Pregnancy.","category":"hypertensie","category_label":"Hypertensie","professions":["huisarts"],"tags":["bloeddrukbehandeling","vrouwen"],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.117.10705","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.117.10705","authors":["Carrie J Nobles","Pauline Mendola","Sunni L Mumford","Ashley I Naimi","Edwina H Yeung","Keewan Kim","Hyojun Park","Brian Wilcox","Robert M Silver","Neil J Perkins","Lindsey Sjaarda","Enrique F Schisterman"],"significance":5,"published":"2018-05-01","source_date":"2018-05-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/cardiovasculaire-risicoschatting-score2/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"This prospective study showed that elevated preconception blood pressure is associated with adverse reproductive outcomes, establishing blood pressure as a modifiable factor for fertility and pregnancy health.","created":"2026-07-03T10:27:16Z","updated":"2026-07-03T18:38:37Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Prospectieve studie naar het verband tussen preconceptionele bloeddruk en reproductieve uitkomsten. Relevant voor preconceptiezorg en cardiovasculaire risicostratificatie.","abstract_original":"UNLABELLED: Elevated blood pressure in young adulthood is an early risk marker for cardiovascular disease. Despite a strong biological rationale, little research has evaluated whether incremental increases in preconception blood pressure have early consequences for reproductive health. We evaluated preconception blood pressure and fecundability, pregnancy loss, and live birth in the EAGeR trial (Effects of Aspirin on Gestational and Reproduction; 2007-2011), a randomized clinical trial of aspirin and reproductive outcomes among 1228 women attempting pregnancy with a history of pregnancy loss. Systolic and diastolic blood pressure were measured during preconception in the first observed menstrual cycle and in early pregnancy and used to derive mean arterial pressure. Fecundability was assessed as number of menstrual cycles until pregnancy, determined through human chorionic gonadotropin testing. Pregnancy loss included both human chorionic gonadotropin-detected and clinical losses. Analyses adjusted for treatment assignment, age, body mass index, race, marital status, smoking, parity, and time since last loss. Mean preconception systolic and diastolic blood pressure were 111.6 mm Hg (SD, 12.1) and 72.5 (SD, 9.4) mm Hg. Risk of pregnancy loss increased 18% per 10 mm Hg increase in diastolic blood pressure (95% confidence interval, 1.03-1.36) and 17% per 10 mm Hg increase in mean arterial pressure (95% confidence interval, 1.02-1.35) in adjusted analyses. Findings were similar for early pregnancy blood pressure. Preconception blood pressure was not related to fecundability or live birth in adjusted analyses. Findings suggest that preconception blood pressure among healthy women is associated with pregnancy loss, and lifestyle interventions targeting blood pressure among young women may favorably impact reproductive health. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00467363."}