# CPAP en cardiovasculaire events bij obstructieve slaapapneu: meta-analyse

*geplaatst 2018-06-21 · Hartfalen · European heart journal · doi 10.1093/eurheartj/ehx597 · https://hartvaat.nl/2018/06/21/cpap-en-cardiovasculaire-events-bij-obstructieve-slaapapneu-meta-analyse/*

Meta-analyse naar het effect van CPAP op cardiovasculaire events bij patiënten met obstructieve slaapapneu. Teleurstellend: geen significante reductie ondanks verbetering van de slaapkwaliteit.

## English: A meta-analysis of continuous positive airway pressure therapy in prevention of cardiovascular events in patients with obstructive sleep apnoea.

This meta-analysis found that CPAP therapy does not significantly reduce major cardiovascular events in patients with obstructive sleep apnea, disappointing expectations that treating nocturnal airway obstruction would translate to cardiovascular protection.

## Abstract (original, from the publication)

AIMS: To assess whether continuous positive airway pressure (CPAP) therapy reduces major adverse cardiovascular events (MACE) in patients with moderate-to-severe obstructive sleep apnoea (OSA). METHODS AND RESULTS: A total of 235 articles were recovered using MEDLINE, EMBASE and Cochrane library (inception-December 2016) and references contained in the identified articles. Seven randomized controlled trials (RCTs) were selected for final analysis. Analysis of 4268 patients demonstrated non-significant 26% relative risk reduction in MACE with CPAP [risk ratio (RR) 0.74; 95% confidence interval (CI) 0.47-1.17; P = 0.19, I2 = 48%]. A series of sensitivity analyses suggested that increased CPAP usage time yielded significant risk reduction in MACE. and stroke. Subgroup analysis revealed that CPAP adherence time ≥4 hours (h)/night reduced the risk of MACE by 57% (RR 0.43; 95% CI 0.23-0.80; P = 0.01, I2 = 0%). CPAP therapy showed no beneficial effect on myocardial infarction (MI), all-cause mortality, atrial fibrillation/flutter (AF), or heart failure (HF) (P > 0.05). CPAP had positive effect on mood and reduced the daytime sleepiness [Epworth Sleepiness Scale (ESS): mean difference (MD) -2.50, 95% CI - 3.62, -1.39; P < 0.001, I2 = 81%]. CONCLUSION: CPAP therapy might reduce MACE and stroke among subjects with CPAP time exceeding 4 h/night. Additional randomized trials mandating adequate CPAP time adherence are required to confirm this impression.

Auteurs: Safi U Khan, Crystal A Duran, Hammad Rahman, Manidhar Lekkala, Muhammad A Saleem, Edo Kaluski

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Bron: European heart journal, https://doi.org/10.1093/eurheartj/ehx597. Bijgewerkt 2026-07-03T13:26:35Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.