# IL-8 en infarctgrootte en klinische uitkomsten bij STEMI

*geplaatst 2018-07-10 · Algemeen · Journal of the American College of Cardiology · doi 10.1016/j.jacc.2018.04.053 · https://hartvaat.nl/2018/07/10/il-8-en-infarctgrootte-en-klinische-uitkomsten-bij-stemi/*

Studie naar de associatie van interleukine-8 met infarctgrootte en klinische uitkomsten bij STEMI. Inflammatiemarker als prognostische tool.

## English: Association of IL-8 With Infarct Size and Clinical Outcomes in Patients With STEMI.

This study showed that IL-8 levels are associated with infarct size and clinical outcomes in STEMI, identifying another inflammatory biomarker in the acute MI pathway.

## Abstract (original, from the publication)

BACKGROUND: Little is known about the role of interleukin (IL)-8 in patients with acute ST-segment elevation myocardial infarction (STEMI). OBJECTIVES: The aims of this study were to evaluate, in STEMI patients, the temporal profile of IL-8 and possible associations with left ventricular (LV) function and remodeling, infarct size, microvascular obstruction, myocardial salvage, and future clinical events. METHODS: A total of 258 patients with STEMI were included. Blood samples were drawn before and immediately after percutaneous coronary intervention (PCI), at day 1, and after 4 months. Cardiac magnetic resonance imaging was performed in the acute phase and after 4 months. Clinical events were registered during 12 months' follow-up and all-cause mortality after median 70 months' follow-up. RESULTS: Patients with IL-8 levels greater than the median measured both immediately after PCI and at day 1 had larger final infarct size, lower LV ejection fraction, larger increase in LV end-diastolic volume, and higher frequency of microvascular obstruction. After multivariate adjustment, high IL-8 levels at day 1 were associated with an increased risk of developing a large MI and having reduced LV ejection fraction at 4 months, also after adjustment for peak troponin value. Patients with IL-8 levels in the highest quartile measured at all sampling points were more likely to have a clinical event during the first 12 months after the MI and had lower overall survival during long-term follow-up. CONCLUSIONS: High levels of circulating IL-8 were associated with large infarct size, impaired recovery of LV function, and adverse clinical outcome in patients with STEMI, suggesting IL-8 as a future therapeutic target based on its important role in post-infarction inflammation.

Auteurs: Christian Shetelig, Shanmuganathan Limalanathan, Pavel Hoffmann, Ingebjørg Seljeflot, Jon M Gran, Jan Eritsland, Geir Ø Andersen

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Bron: Journal of the American College of Cardiology, https://doi.org/10.1016/j.jacc.2018.04.053. Bijgewerkt 2026-07-03T13:26:37Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.