{"id":"169f18701fef","type":"article","url":"https://hartvaat.nl/2018/11/01/kwaliteit-van-leven-na-mitralisklepchirurgie-met-en-zonder-epicardiale-cryoablat/","title":"Kwaliteit van leven na mitralisklepchirurgie met en zonder epicardiale cryoablatie voor AF","title_en":"Quality of life is not improved after mitral valve surgery combined with epicardial left atrial cryoablation as compared with mitral valve surgery alone: a substudy of the double blind randomized SWEDish Multicentre Atrial Fibrillation study (SWEDMAF).","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog"],"tags":["cryoablatie","laminopathie"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/eux253","source_url":"https://doi.org/10.1093/europace/eux253","authors":["Louise Bagge","Johan Probst","Steen M Jensen","Per Blomström","Stefan Thelin","Anders Holmgren","Carina Blomström-Lundqvist"],"significance":5,"published":"2018-11-01","source_date":"2018-11-01","image":"","kennis":[],"congress":"","summary_en":"This study showed that adding epicardial cryoablation to mitral valve surgery does not improve quality of life despite increasing freedom from AF, questioning the value of concomitant surgical ablation when the patient perspective is prioritized.","created":"2026-07-03T10:27:35Z","updated":"2026-07-03T13:26:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat toevoeging van epicardiale linkeratriale cryoablatie aan mitralisklepchirurgie de kwaliteit van leven niet verbetert.","abstract_original":"AIMS: Concomitant surgical ablation of atrial fibrillation (AF) in patients undergoing mitral valve surgery (MVS) has almost become routine despite lack of convincing information about improved quality-of-life (QOL) and clinical benefit. Quality-of-life was therefore assessed after MVS with or without epicardial left atrial cryoablation. METHODS AND RESULTS: Sixty-five patients with permanent AF randomized to MVS with or without left atrial cryoablation, in the double-blinded multicentre SWEDMAF trial, replied to the Short Form 36 QOL survey at 6 and 12 months follow-up. The QOL scores at 12 month follow-up did not differ significantly between patients undergoing MVS combined with cryoablation vs. those undergoing MVS alone regarding Physical Component Summary mean 42.8 (95% confidence interval 38.3-47.3) vs. mean 44.0 (40.1-47.7), P = 0.700 or Mental Component Summary mean 53.1 (49.7-56.4) vs. mean 48.4 (44.6-52.2), P = 0.075. All patients, irrespective of allocated procedure, reached the same QOL after surgery as an age-matched Swedish general population. The Physical Component Summary in patients with sinus rhythm did also not differ from those in AF at 12 months; mean 45.4 (42.0-48.7) vs. mean 40.5 (35.5-45.6), P = 0.096) nor was there a difference in Mental Component Summary; mean 51.0 (48.0-54.1) vs. mean 49.6 (44.6-54.5), P = 0.581). CONCLUSION: Left atrial cryoablation added to MVS does not improve health-related QOL in patients with permanent AF, a finding that raises concerns regarding recommendations made for this combined procedure."}