{"id":"6ecd2fc36a00","type":"article","url":"https://hartvaat.nl/2018/11/01/longitudinale-bloeddrukverandering-en-cv-mortaliteit-in-een-chinees-cohort/","title":"Longitudinale bloeddrukverandering en CV-mortaliteit in een Chinees cohort","title_en":"Longitudinal change in blood pressure is associated with cardiovascular disease mortality in a Chinese cohort.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":["ouderen","vrouwen"],"journal":"Heart (British Cardiac Society)","doi":"10.1136/heartjnl-2017-312850","source_url":"https://doi.org/10.1136/heartjnl-2017-312850","authors":["Jin-Hu Fan","Jian-Bing Wang","Shao-Ming Wang","Christian C Abnet","You-Lin Qiao","Philip R Taylor"],"significance":5,"published":"2018-11-01","source_date":"2018-11-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/cardiovasculaire-risicoschatting-score2/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"This large Chinese cohort study showed that longitudinal blood pressure changes, rather than single measurements, are strongly associated with cardiovascular mortality, supporting dynamic blood pressure monitoring over time.","created":"2026-07-03T10:27:35Z","updated":"2026-07-03T13:26:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die het verband onderzocht tussen longitudinale bloeddrukverandering en cardiovasculaire mortaliteit in een groot Chinees cohort.","abstract_original":"BACKGROUND: A number of studies have demonstrated a J-shaped curve between blood pressure (BP) and all-cause mortality, but few studies have used longitudinal change in BP to study mortality in the Chinese population. METHODS: We performed a 30-year follow-up study to examine the association between BP (at baseline and longitudinal change) and risk of mortality in the Linxian General Population Trial Cohort. At baseline, a total of 29 584 healthy adults were enrolled in the Linxian General Population Trial in 1985 and followed through to the end of 2014. The final analysis was restricted to 29 439 participants (55% women) after exclusion of outliers. We also examined the potential effects of BP trajectory patterns during the period of 1985-1999 on sequent risk of mortality. Adjusted Cox proportional hazards models were used to estimate HRs and 95% CIs. RESULTS: Compared with participants with normal BP, patients with prehypertension, stage 1, stage 2 or stage 3 hypertension had an increased risk of all-cause mortality, with HRs of 1.09 (95% CI 1.05 to 1.14), 1.34 (95% CI 1.28 to 1.40), 1.69 (95% CI 1.60 to 1.79) and 2.14 (95% CI 2.01 to 2.28), respectively. Relative to stable BP of normotension, having a rise in BP from normotension to hypertension or from prehypertension to hypertension both conferred an increased risk of total and cardiovascular disease and stroke mortality (total: HRs 1.22 (95% CI 1.12 to 1.34) and 1.36 (95% CI 1.23 to 1.51); cardiovascular disease: HRs 1.42 (95% CI 1.17 to 1.73) and 1.55 (95% CI 1.24 to 1.93); stroke: HRs 2.29 (95% CI 1.88 to 2.80) and 2.61 (95% CI 2.11 to 3.24), respectively). CONCLUSIONS: These findings emphasise that development of incident hypertension in middle age could increase the risk of total, cardiovascular disease and stroke mortality, and suggest that current BP targets could be revised. TRIAL REGISTRATION NUMBER: NCT00342654;Post-results."}