{"id":"f23836e2fc0a","type":"article","url":"https://hartvaat.nl/2018/11/21/voortzetten-versus-onderbreken-doac-bij-device-chirurgie-bruise-control-2/","title":"Voortzetten versus onderbreken DOAC bij device-chirurgie: BRUISE CONTROL-2","title_en":"Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2).","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["apotheker","cardioloog"],"tags":[],"journal":"European heart journal","doi":"10.1093/eurheartj/ehy413","source_url":"https://doi.org/10.1093/eurheartj/ehy413","authors":["David H Birnie","Jeff S Healey","George A Wells","Felix Ayala-Paredes","Benoit Coutu","Glen L Sumner","Giuliano Becker","Atul Verma","François Philippon","Eli Kalfon","John Eikelboom","Roopinder K Sandhu","Pablo B Nery","Nicholas Lellouche","Stuart J Connolly","John Sapp","Vidal Essebag"],"significance":7,"published":"2018-11-21","source_date":"2018-11-21","image":"","kennis":["https://hartvaat.nl/kennis/antistolling/doac-versus-vka-keuze/"],"congress":"","summary_en":"The BRUISE CONTROL-2 trial examined whether continuing DOACs versus heparin bridging during pacemaker or ICD surgery reduces pocket hematoma and bleeding complications, extending the uninterrupted anticoagulation approach from warfarin to DOACs.","created":"2026-07-03T10:27:36Z","updated":"2026-07-03T13:26:50Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"BRUISE CONTROL-2 gerandomiseerde trial naar ononderbroken versus onderbroken DOAC bij pacemaker/ICD-chirurgie bij patiënten met matig tot hoog trombotisch risico.","abstract_original":"AIMS: Guidelines recommend warfarin continuation rather than heparin bridging for pacemaker and defibrillator surgery, after the BRUISE CONTROL trial demonstrated an 80% reduction in device pocket haematoma with this approach. However, direct oral anticoagulants (DOACs) are now used to treat the majority of patients with atrial fibrillation. We sought to understand the best strategy to manage the DOACs at the time of device surgery and specifically hypothesized that performing device surgery without DOAC interruption would result in a reduced haematoma rate. METHODS AND RESULTS: We randomly assigned patients with atrial fibrillation and CHA2DS2-VASc score ≥2, to continued vs. interrupted DOAC (dabigatran, rivaroxaban, or apixaban). The primary outcome was blindly evaluated, clinically significant device pocket haematoma: resulting in re-operation, interruption of anticoagulation, or prolonging hospital stay. In the continued arm, the median time between pre- and post-operative DOAC doses was 12 h; in the interrupted arm the median time was 72 h. Clinically significant haematoma occurred in of 7 of 328 (2.1%; 95% CI 0.9-4.3) patients in the continued DOAC arm and 7 of 334 (2.1%; 95% CI 0.9-4.3) patients in the interrupted DOAC arm (P = 0.97). Complications were uncommon, and included one stroke and one symptomatic pericardial effusion in each arm. CONCLUSIONS: These results suggest that, dependent on the clinical scenario, either management strategy (continued DOAC or interrupted DOAC) might be reasonable, at least for patients similar to those enrolled in our trial."}