{"id":"e4c9043f7bf2","type":"article","url":"https://hartvaat.nl/2018/12/04/ffr-versus-angiografie-geleide-cabg/","title":"FFR versus angiografie-geleide CABG","title_en":"Fractional Flow Reserve Versus Angiographically-Guided Coronary Artery Bypass Grafting.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2018.09.043","source_url":"https://doi.org/10.1016/j.jacc.2018.09.043","authors":["Anne Langhoff Thuesen","Lars Peter Riber","Karsten Tange Veien","Evald Høj Christiansen","Svend Eggert Jensen","Ivy Modrau","Jan Jesper Andreasen","Anders Junker","Poul Erik Mortensen","Lisette Okkels Jensen"],"significance":7,"published":"2018-12-04","source_date":"2018-12-04","image":"","kennis":["https://hartvaat.nl/kennis/coronairlijden/coronaire-angiografie-hartkatheterisatie/"],"congress":"","summary_en":"This study compared FFR-guided versus angiography-guided CABG planning, investigating whether physiological assessment of coronary stenosis severity improves graft patency and clinical outcomes after bypass surgery.","created":"2026-07-03T10:27:38Z","updated":"2026-07-03T13:26:52Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die FFR-geleide vergeleek met angiografie-geleide CABG-strategie. Onderzoekt of functionele evaluatie de CABG-planning verbetert.","abstract_original":"BACKGROUND: The value of fractional flow reserve (FFR) evaluation of coronary artery stenosis in coronary artery bypass grafting (CABG) is uncertain, and stenosis assessments usually rely on visual estimates of lesion severity. OBJECTIVES: This randomized clinical trial evaluated graft patency and clinical outcome after FFR-guided CABG versus angiography-guided CABG. METHODS: A total of 100 patients referred for CABG were randomly assigned to FFR-guided or angiography-guided CABG. Based on the coronary angiogram, a heart team made a graft plan for all patients, and FFR evaluations were performed. In FFR-guided CABG, coronary lesions with FFR >0.80 were deferred, and a new graft plan was designed accordingly, whereas the surgeon was blinded to the FFR values in patients who underwent angiography-guided CABG. The primary endpoint was graft failure in the percentage of all grafts after 6 months. RESULTS: Angiographic follow-up at 6 months was available for 72 patients (39 vs. 33 in the FFR-guided and angiography-guided groups, respectively). Graft failures of all grafts were similar in both groups (16% vs. 12%; p = 0.97). Rates of death, myocardial infarction, and stroke were also similar in the study groups, and no difference was seen in revascularization before angiographic follow-up. After 6 months, deferred lesions (n = 24) showed a significant reduction in mean FFR from index to follow-up (0.89 ± 0.05 vs. 0.81 ± 0.11; p = 0.002). Index FFR did not influence graft patency. CONCLUSIONS: FFR-guided CABG had similar graft failure rates and clinical outcomes as angiography-guided CABG. However, FFR was reduced significantly after 6 months in deferred lesions. (Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization [FARGO]; NCT02477371)."}