{"id":"6185282546d5","type":"article","url":"https://hartvaat.nl/2019/01/01/acute-creatininestijging-bij-start-ace-remmer-en-effecten-van-voortzetting-analy/","title":"Acute creatininestijging bij start ACE-remmer en effecten van voortzetting: analyse","title_en":"Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus.","category":"preventie","category_label":"Preventie","professions":["cardioloog","huisarts","internist"],"tags":["ace-remmers","acuut-hartfalen","cardiorenal-behandelstrategie","ras-remmers"],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.118.12060","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.118.12060","authors":["Toshiaki Ohkuma","Min Jun","Anthony Rodgers","Mark E Cooper","Paul Glasziou","Pavel Hamet","Stephen Harrap","Giuseppe Mancia","Michel Marre","Bruce Neal","Vlado Perkovic","Neil Poulter","Bryan Williams","Sophia Zoungas","John Chalmers","Mark Woodward"],"significance":7,"published":"2019-01-01","source_date":"2019-01-01","image":"","kennis":[],"congress":"","summary_en":"This study showed that acute creatinine increases after starting ACE inhibitor therapy do not necessarily indicate kidney damage and that continuation of treatment leads to better long-term outcomes than discontinuation, challenging traditional concerns about RAAS inhibitor-related creatinine rises.","created":"2026-07-03T10:27:41Z","updated":"2026-07-03T13:26:54Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie naar acute creatininestijging bij start van ACE-remmerbehandeling en de effecten van voortzetting versus staken. Nuanceert de reactie op initiële nierfunctieverandering.","abstract_original":"Discontinuation of angiotensin-converting enzyme (ACE) inhibitor is recommended if patients experience ≥30% acute increase in serum creatinine after starting this therapy. However, the long-term effects of its continuation or discontinuation on major clinical outcomes after increases in serum creatinine are unclear. In the ADVANCE trial (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation), 11 140 diabetes mellitus patients were randomly assigned to perindopril-indapamide or placebo after a 6-week active run-in period. The current study included 11 066 participants with 2 serum creatinine measurements recorded before and during the active run-in period (3 weeks apart). Acute increase in creatinine was determined using these 2 measurements and classified into 4 groups: increases in serum creatinine of <10%, 10% to 19%, 20% to 29%, and ≥30%. The primary study outcome was the composite of major macrovascular events, new or worsening nephropathy, and all-cause mortality. An acute increase in serum creatinine was associated with an elevated risk of the primary outcome ( P for trend <0.001). The hazard ratios were 1.11 (95% CI, 0.97-1.28) for those with an increase of 10% to 19%, 1.34 (1.07-1.66) for 20% to 29%, and 1.44 (1.15-1.81) for ≥30%, compared with <10%. However, there was no evidence of heterogeneity in the benefit of randomized treatment effects on the outcome across subgroups defined by acute serum creatinine increase ( P for heterogeneity=0.94). Acute increases in serum creatinine after starting perindopril-indapamide were associated with greater risks of subsequent major clinical outcomes. However, the continuation of angiotensin-converting enzyme inhibitor-based therapy reduced the long-term risk of major clinical outcomes, irrespective of acute increase in creatinine. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT00145925."}