# Tricuspidalisinsufficiëntie en mortaliteit onafhankelijk van PH en rechterventrikelfalen: meta-analyse

*geplaatst 2019-02-01 · Hartfalen · European heart journal · doi 10.1093/eurheartj/ehy641 · https://hartvaat.nl/2019/02/01/tricuspidalisinsufficientie-en-mortaliteit-onafhankelijk-van-ph-en-rechterventri/*

Systematische review die aantoont dat tricuspidalisinsufficiëntie onafhankelijk geassocieerd is met verhoogde mortaliteit. Ondersteunt vroegere interventie bij TR.

## English: Tricuspid regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure: a systematic review and meta-analysis.

This systematic review and meta-analysis demonstrated that tricuspid regurgitation severity is independently associated with increased mortality regardless of pulmonary pressures and right heart function, establishing TR as an independent prognostic marker.

## Abstract (original, from the publication)

AIMS: To undertake a systematic review and meta-analysis to determine the influence of tricuspid regurgitation (TR) severity on mortality. METHODS AND RESULTS: We performed a systematic search for studies reporting clinical outcomes of patients with TR. The primary endpoint was all-cause mortality and secondary endpoints were cardiac mortality and hospitalization for heart failure (HF). Overall risk ratios (RR) and 95% confidence intervals (CIs) were derived for each endpoint according to the severity of TR by meta-analysing the effect estimates of eligible studies. Seventy studies totalling 32 601 patients were included in the analysis, with a mean (±SD) follow-up of 3.2 ± 2.1 years. Moderate/severe TR was associated with a two-fold increased mortality risk compared to no/mild TR (RR 1.95, 95% CI 1.75-2.17). Moderate/severe TR remained associated with higher all-cause mortality among 13 studies which adjusted for systolic pulmonary arterial pressures (RR 1.85, 95% CI 1.44-2.39), and 15 studies, which adjusted for right ventricular (RV) dysfunction (RR 1.78, 95% CI 1.49-2.13). Moderate/severe TR was also associated with increased cardiac mortality (RR 2.56, 95% CI 1.84-3.55) and HF hospitalization (RR 1.73, 95% CI 1.14-2.62). Compared to patients with no TR, patients with mild, moderate, and severe TR had a progressively increased risk of all-cause mortality (RR 1.25, 1.61, and 3.44, respectively; P < 0.001 for trend). CONCLUSIONS: Moderate/severe TR is associated with an increased mortality risk, which appears to be independent of pulmonary pressures and RV dysfunction.

Auteurs: Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Michele McGrady, Ian Wilcox, David Celermajer, Sean Lal

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Bron: European heart journal, https://doi.org/10.1093/eurheartj/ehy641. Bijgewerkt 2026-07-03T13:26:58Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.