{"id":"c24512c01b43","type":"article","url":"https://hartvaat.nl/2019/03/01/natriumreductie-tot-1000-mg-dag-vermindert-neurovasculaire-transductie-zonder-sy/","title":"Natriumreductie tot 1000 mg/dag vermindert neurovasculaire transductie zonder sympathische activatie","title_en":"Reducing Dietary Sodium to 1000 mg per Day Reduces Neurovascular Transduction Without Stimulating Sympathetic Outflow.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":[],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.118.12074","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.118.12074","authors":["Matthew C Babcock","Austin T Robinson","Kamila U Migdal","Joseph C Watso","Megan M Wenner","Sean D Stocker","William B Farquhar"],"significance":5,"published":"2019-03-01","source_date":"2019-03-01","image":"","kennis":[],"congress":"","summary_en":"This study demonstrated that extreme sodium reduction to 1,000 mg/day reduces neurovascular transduction without triggering compensatory sympathetic activation, supporting aggressive dietary sodium targets for blood pressure management.","created":"2026-07-03T10:27:48Z","updated":"2026-07-03T13:27:00Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat extreme natriumreductie de neurovasculaire transductie verbetert zonder compensatoire sympathische activatie.","abstract_original":"The American Heart Association recommends no more than 1500 mg of sodium/day as ideal. Some cohort studies suggest low-sodium intake is associated with increased cardiovascular mortality. Extremely low-sodium diets (≤500 mg/d) elicit activation of the renin-angiotensin-aldosterone system and stimulate sympathetic outflow. The effects of an American Heart Association-recommended diet on sympathetic regulation of the vasculature are unclear. Therefore, we assessed whether a 1000 mg/d diet alters sympathetic outflow and sympathetic vascular transduction compared with the more commonly recommended 2300 mg/d. We hypothesized that sodium reduction from 2300 to 1000 mg/d would not affect resting sympathetic outflow but would reduce sympathetic transduction in healthy young adults. Seventeen participants (age: 26±2 years, 9F/8M) completed 10-day 2300 and 1000 mg/d sodium diets in this randomized controlled feeding study (crossover). We measured resting renin activity, angiotensin II, aldosterone, blood pressure, muscle sympathetic nerve activity, and norepinephrine. We quantified beat-by-beat changes in mean arterial pressure and leg vascular conductance (femoral artery ultrasound) following spontaneous sympathetic bursts to assess sympathetic vascular transduction. Reducing sodium to 1000 mg/d increased renin activity, angiotensin II, and aldosterone ( P<0.01 for all) but did not alter mean arterial pressure (78±2 versus 77±2 mm Hg, P=0.56), muscle sympathetic nerve activity (13.9±1.3 versus 13.9±0.8 bursts/min, P=0.98), or plasma/urine norepinephrine. Sympathetic vascular transduction decreased ( P<0.01). These data suggest that reducing sodium from 2300 to 1000 mg/d stimulates the renin-angiotensin-aldosterone system, does not increase resting basal sympathetic outflow, and reduces sympathetic vascular transduction in normotensive adults."}