{"id":"0fe2d2de71bc","type":"article","url":"https://hartvaat.nl/2019/06/01/icd-implantatie-en-gezondheidsgerelateerde-kwaliteit-van-leven-danish/","title":"ICD-implantatie en gezondheidsgerelateerde kwaliteit van leven: DANISH","title_en":"The impact of implantable cardioverter-defibrillator implantation on health-related quality of life in the DANISH trial.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":[],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euz018","source_url":"https://doi.org/10.1093/europace/euz018","authors":["Johan S Bundgaard","Jens J Thune","Jens C Nielsen","Regitze Videbæk","Jens Haarbo","Niels E Bruun","Lars Videbæk","David Aagaard","Eva Korup","Gunnar Jensen","Per Hildebrandt","Flemming H Steffensen","Hans Eiskjær","Axel Brandes","Anna M Thøgersen","Thomas M Melchior","Ole D Pedersen","Finn Gustafsson","Kenneth Egstrup","Christian Hassager","Jesper H Svendsen","Dan E Høfsten","Christian Torp-Pedersen","Susanne S Pedersen","Steen Pehrson","Lars Køber","Ulrik M Mogensen"],"significance":6,"published":"2019-06-01","source_date":"2019-06-01","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/palliatief-hartfalen/","https://hartvaat.nl/kennis/hartfalen/icd-bij-hartfalen/"],"congress":"","summary_en":"This DANISH trial analysis showed that ICD implantation does not significantly impact health-related quality of life in non-ischemic heart failure patients, adding patient-centered data to the neutral mortality finding.","created":"2026-07-03T10:27:58Z","updated":"2026-07-03T13:27:10Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"DANISH-trial analyse naar de impact van ICD-implantatie op gezondheidsgerelateerde kwaliteit van leven bij niet-ischemisch hartfalen.","abstract_original":"AIM: The Danish Study to Assess the Efficacy of Implantable Cardioverter-Defibrillators (ICD) in Patients with Non-ischaemic Systolic Heart Failure (HF) on Mortality (DANISH) found no overall effect on all-cause mortality. The effect of ICD implantation on health-related quality of life (HRQoL) remains to be established as previous trials have demonstrated conflicting results. We investigated the impact of ICD implantation on HRQoL in patients with non-ischaemic systolic HF, a prespecified secondary endpoint in DANISH. METHODS AND RESULTS: In DANISH, a total of 1116 patients with non-ischaemic systolic HF were randomly assigned (1:1) to ICD implantation or usual clinical care (control). Patients completed disease-specific HRQoL as assessed by Minnesota Living with Heart Failure Questionnaire (MLHFQ; 0-105, high indicating worse). Changes in HRQoL 8 months after randomization were assessed with a mixed-effects model. At randomization, MLHFQ was completed by 935 (84%) patients (n = 472 in the ICD group and n = 463 in the control group) and was reassessed in 274 (58%) and 292 (63%) patients, respectively after 8 months for the primary analysis. Patients in the ICD group vs. the control group had similar improvements in MLHFQ after 8 months [least square mean -7.0 vs. -4.2 (P = 0.13)]. A clinically relevant improvement (decrease ≥5) in the MLHFQ overall score at 8 months was observed in 151 patients in the ICD group and 148 patients in the control group [55% vs. 51%, respectively (P = 0.25)]. CONCLUSION: Implantable cardioverter-defibrillator implantation in patients with non-ischaemic systolic HF did not significantly alter HRQoL compared with patients randomized to usual clinical care."}