{"id":"b62a2bf6baf5","type":"article","url":"https://hartvaat.nl/2019/08/20/dna-methylering-in-leukocyten-voorspelt-mi-en-coronairlijden/","title":"DNA-methylering in leukocyten voorspelt MI en coronairlijden","title_en":"Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.118.039357","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.118.039357","authors":["Golareh Agha","Michael M Mendelson","Cavin K Ward-Caviness","Roby Joehanes","TianXiao Huan","Rahul Gondalia","Elias Salfati","Jennifer A Brody","Giovanni Fiorito","Jan Bressler","Brian H Chen","Symen Ligthart","Simonetta Guarrera","Elena Colicino","Allan C Just","Simone Wahl","Christian Gieger","Amy R Vandiver","Toshiko Tanaka","Dena G Hernandez","Luke C Pilling","Andrew B Singleton","Carlotta Sacerdote","Vittorio Krogh","Salvatore Panico","Rosario Tumino","Yun Li","Guosheng Zhang","James D Stewart","James S Floyd","Kerri L Wiggins","Jerome I Rotter","Michael Multhaup","Kelly Bakulski","Steven Horvath","Philip S Tsao","Devin M Absher","Pantel Vokonas","Joel Hirschhorn","M Daniele Fallin","Chunyu Liu","Stefania Bandinelli","Eric Boerwinkle","Abbas Dehghan","Joel D Schwartz","Bruce M Psaty","Andrew P Feinberg","Lifang Hou","Luigi Ferrucci","Nona Sotoodehnia","Giuseppe Matullo","Annette Peters","Myriam Fornage","Themistocles L Assimes","Eric A Whitsel","Daniel Levy","Andrea A Baccarelli"],"significance":6,"published":"2019-08-20","source_date":"2019-08-20","image":"","kennis":[],"congress":"","summary_en":"This study demonstrated that DNA methylation patterns in blood leukocytes predict future myocardial infarction and coronary heart disease risk, advancing epigenetic biomarkers as novel cardiovascular risk predictors.","created":"2026-07-03T10:28:06Z","updated":"2026-07-03T13:27:17Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat DNA-methyleringspatronen in leukocyten het risico op toekomstig MI en coronairlijden voorspellen. Epigenetische risicostratificatie.","abstract_original":"BACKGROUND: DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts. METHODS: Nine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effect meta-analyses across cohorts. RESULTS: Among 11 461 individuals (mean age 64 years, 67% women, 35% African American) free of CHD at baseline, 1895 developed CHD during a mean follow-up of 11.2 years. Methylation levels at 52 CpG (cytosine-phosphate-guanine) sites were associated with incident CHD or myocardial infarction (false discovery rate<0.05). These CpGs map to genes with key roles in calcium regulation (ATP2B2, CASR, GUCA1B, HPCAL1), and genes identified in genome- and epigenome-wide studies of serum calcium (CASR), serum calcium-related risk of CHD (CASR), coronary artery calcified plaque (PTPRN2), and kidney function (CDH23, HPCAL1), among others. Mendelian randomization analyses supported a causal effect of DNA methylation on incident CHD; these CpGs map to active regulatory regions proximal to long non-coding RNA transcripts. CONCLUSION: Methylation of blood-derived DNA is associated with risk of future CHD across diverse populations and may serve as an informative tool for gaining further insight on the development of CHD."}