{"id":"8f5ef625c84a","type":"article","url":"https://hartvaat.nl/2019/10/01/lage-arteriele-compliance-en-cv-morbiditeit-bij-aortaklepstenose/","title":"Lage arteriële compliance en CV-morbiditeit bij aortaklepstenose","title_en":"Low systemic arterial compliance is associated with increased cardiovascular morbidity and mortality in aortic valve stenosis.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog"],"tags":["aortainsufficiëntie","aortastenose","perifeer-vaatlijden"],"journal":"Heart (British Cardiac Society)","doi":"10.1136/heartjnl-2018-314386","source_url":"https://doi.org/10.1136/heartjnl-2018-314386","authors":["Edda Bahlmann","Dana Cramariuc","Sahrai Saeed","John B Chambers","Christoph A Nienaber","Karl-Heinz Kuck","Mai Tone Lønnebakken","Eva Gerdts"],"significance":6,"published":"2019-10-01","source_date":"2019-10-01","image":"","kennis":[],"congress":"","summary_en":"This study showed that low systemic arterial compliance is independently associated with increased cardiovascular morbidity and mortality in aortic stenosis, adding a hemodynamic parameter beyond traditional valve severity measures.","created":"2026-07-03T10:28:10Z","updated":"2026-07-03T13:27:21Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat lage systemische arteriële compliance geassocieerd is met verhoogde CV-morbiditeit en mortaliteit bij aortaklepstenose.","abstract_original":"OBJECTIVE: Lower systemic arterial compliance (SAC) is associated with increased cardiovascular morbidity and mortality in hypertension, but this has not been assessed in a prospective study in aortic valve stenosis (AS). METHODS: Data from 1641 patients (38% women) with initially asymptomatic mild-moderate AS enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Median follow-up was 4.3 years. SAC was assessed from Doppler stroke volume index to central pulse pressure ratio and considered low if ≤0.64 mL/m², corresponding to the lower tertile in the population. The association of SAC with outcome was assessed in Cox regression analysis and reported as HR and 95% CI. RESULTS: Low SAC at baseline was characterised by older age, female sex, hypertension, obesity, presence of a small aortic root, lower mean aortic gradient and more severe AS by effective aortic valve area (all p<0.01). In Cox regression analysis adjusting for factors, low SAC was associated with higher HRs for cardiovascular death (HR 2.13(95% CI 1.34 to 3.40) and all-cause mortality (HR 1.71(95% CI 1.23 to 2.38)), both p=0.001). The results did not change when systolic or diastolic blood pressure, other measures of AS severity or presence of discordantly graded AS were included in subsequent models. Presence of low SAC did not improve mortality prediction in reclassification analysis. CONCLUSIONS: In patients with AS without diabetes and known cardiovascular disease, but a high prevalence of hypertension, low SAC was associated with higher cardiovascular and all-cause mortality independent of well-known prognosticators. TRIAL REGISTRATION NUMBER: NCT00092677; Post-results."}