{"id":"4dee2b34005d","type":"article","url":"https://hartvaat.nl/2019/11/21/ticagrelor-met-of-zonder-aspirine-na-pci-bij-hoog-risico-nejm-twilight/","title":"Ticagrelor met of zonder aspirine na PCI bij hoog risico: NEJM TWILIGHT","title_en":"Ticagrelor with or without Aspirin in High-Risk Patients after PCI.","category":"algemeen","category_label":"Algemeen","professions":["apotheker","cardioloog"],"tags":["trombocytenaggregatieremmers"],"journal":"The New England journal of medicine","doi":"10.1056/NEJMoa1908419","source_url":"https://doi.org/10.1056/NEJMoa1908419","authors":["Roxana Mehran","Usman Baber","Samin K Sharma","David J Cohen","Dominick J Angiolillo","Carlo Briguori","Jin Y Cha","Timothy Collier","George Dangas","Dariusz Dudek","Vladimír Džavík","Javier Escaned","Robert Gil","Paul Gurbel","Christian W Hamm","Timothy Henry","Kurt Huber","Adnan Kastrati","Upendra Kaul","Ran Kornowski","Mitchell Krucoff","Vijay Kunadian","Steven O Marx","Shamir R Mehta","David Moliterno","E Magnus Ohman","Keith Oldroyd","Gennaro Sardella","Samantha Sartori","Richard Shlofmitz","P Gabriel Steg","Giora Weisz","Bernhard Witzenbichler","Ya-Ling Han","Stuart Pocock","C Michael Gibson"],"significance":10,"published":"2019-11-21","source_date":"2019-11-21","image":"","kennis":["https://hartvaat.nl/kennis/coronairlijden/stemi/","https://hartvaat.nl/kennis/antistolling/dubbele-antistolling-indicaties/"],"congress":"","summary_en":"The TWILIGHT trial showed that ticagrelor monotherapy after 3 months of dual antiplatelet therapy significantly reduced clinically relevant bleeding without increasing ischemic events in high-risk patients after PCI. This established P2Y12 inhibitor monotherapy as a safe de-escalation strategy for selected patients.","created":"2026-07-03T10:28:16Z","updated":"2026-07-03T13:27:27Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Landmark NEJM TWILIGHT-trial die aantoonde dat ticagrelor monotherapie (na 3 maanden DAPT) het bloedingsrisico significant vermindert zonder meer ischemische events bij hoogrisico-PCI. Paradigma van P2Y12-monotherapie.","abstract_original":"BACKGROUND: Monotherapy with a P2Y12 inhibitor after a minimum period of dual antiplatelet therapy is an emerging approach to reduce the risk of bleeding after percutaneous coronary intervention (PCI). METHODS: In a double-blind trial, we examined the effect of ticagrelor alone as compared with ticagrelor plus aspirin with regard to clinically relevant bleeding among patients who were at high risk for bleeding or an ischemic event and had undergone PCI. After 3 months of treatment with ticagrelor plus aspirin, patients who had not had a major bleeding event or ischemic event continued to take ticagrelor and were randomly assigned to receive aspirin or placebo for 1 year. The primary end point was Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding. We also evaluated the composite end point of death from any cause, nonfatal myocardial infarction, or nonfatal stroke, using a noninferiority hypothesis with an absolute margin of 1.6 percentage points. RESULTS: We enrolled 9006 patients, and 7119 underwent randomization after 3 months. Between randomization and 1 year, the incidence of the primary end point was 4.0% among patients randomly assigned to receive ticagrelor plus placebo and 7.1% among patients assigned to receive ticagrelor plus aspirin (hazard ratio, 0.56; 95% confidence interval [CI], 0.45 to 0.68; P<0.001). The difference in risk between the groups was similar for BARC type 3 or 5 bleeding (incidence, 1.0% among patients receiving ticagrelor plus placebo and 2.0% among patients receiving ticagrelor plus aspirin; hazard ratio, 0.49; 95% CI, 0.33 to 0.74). The incidence of death from any cause, nonfatal myocardial infarction, or nonfatal stroke was 3.9% in both groups (difference, -0.06 percentage points; 95% CI, -0.97 to 0.84; hazard ratio, 0.99; 95% CI, 0.78 to 1.25; P<0.001 for noninferiority). CONCLUSIONS: Among high-risk patients who underwent PCI and completed 3 months of dual antiplatelet therapy, ticagrelor monotherapy was associated with a lower incidence of clinically relevant bleeding than ticagrelor plus aspirin, with no higher risk of death, myocardial infarction, or stroke. (Funded by AstraZeneca; TWILIGHT ClinicalTrials.gov number, NCT02270242.)."}