# HIIT en plaatjesfunctie bij hartrevalidatie: gerandomiseerde trial

*geplaatst 2020-01-01 · Algemeen · Heart (British Cardiac Society) · doi 10.1136/heartjnl-2019-315130 · https://hartvaat.nl/2020/01/01/hiit-en-plaatjesfunctie-bij-hartrevalidatie-gerandomiseerde-trial/*

Gerandomiseerde trial naar het effect van hoog-intensieve intervaltraining op plaatjesfunctie bij hartrevalidatie.

## English: Effects of high-intensity interval training on platelet function in cardiac rehabilitation: a randomised controlled trial.

This randomized trial compared the effects of high-intensity interval training versus moderate continuous training on platelet function in cardiac rehabilitation patients, evaluating exercise-induced platelet modulation.

## Abstract (original, from the publication)

OBJECTIVE: To compare effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on platelet function in patients undergoing cardiac rehabilitation, as hyper-reactive platelets are involved in atherogenesis and atherothrombosis. METHODS: In this single-centre parallel group randomised controlled trial, male patients after an acute coronary syndrome under dual antiplatelet therapy performed MICT or HIIT+MICT for 12 weeks. Main outcome was platelet reactivity measured by the half-maximal concentration (EC50) of platelet agonist thrombin receptor-activating peptide-6 (TRAP-6) in terms of P-selectin expression. EC50 was determined at baseline, after 6 and 12 weeks, each time at physical rest and on exertion. RESULTS: 82 patients were randomised to MICT or HIIT+MICT. Mean (95% CI) baseline EC50values at physical rest were 6.7 µM (6.3 µM to 7.0 µM) TRAP-6. After 6/12 weeks, 36/33 MICT and 34/28 HIIT+MICT patients were examined. HIIT+MICT patients had 0.9 µM (0.4 µM to 1.4 µM)/0.5 µM (-0.1 µM to 1.0 µM) higher EC50values than MICT ones, and the propensity of their platelets to form aggregates with monocytes was significantly lower after 12 weeks. Short-term strenuous physical exertion was generally associated with platelet activation and an EC50reduction of 0.7 µM (0.6 µM to 0.8 µM). HIIT+MICT patients tended to be fitter after 12 weeks. No serious harms were observed. CONCLUSIONS: Including HIIT in cardiac rehabilitation seems to confer additional benefits compared with MICT alone, which should be confirmed in clinical trials with hard endpoints. Exertion-induced platelet activation and hyper-reactivity occur despite dual antiplatelet therapy. TRIAL REGISTRATION NUMBER: NCT02930330; Results.

Auteurs: Stefan Heber, Beatrix Fischer, Marina Sallaberger-Lehner, Maria Hausharter, Helmuth Ocenasek, Andreas Gleiss, Michael J M Fischer, Rochus Pokan, Alice Assinger, Ivo Volf

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Bron: Heart (British Cardiac Society), https://doi.org/10.1136/heartjnl-2019-315130. Bijgewerkt 2026-07-03T13:27:31Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.