{"id":"e0f36c4f9aa0","type":"article","url":"https://hartvaat.nl/2020/01/01/stapsgewijze-af-screening-met-nt-probnp-strokestop-ii-resultaten/","title":"Stapsgewijze AF-screening met NT-proBNP: STROKESTOP II resultaten","title_en":"Stepwise mass screening for atrial fibrillation using N-terminal B-type natriuretic peptide: the STROKESTOP II study.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog","huisarts"],"tags":["nt-probnp","primaire-preventie"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euz255","source_url":"https://doi.org/10.1093/europace/euz255","authors":["Katrin Kemp Gudmundsdottir","Tove Fredriksson","Emma Svennberg","Faris Al-Khalili","Leif Friberg","Viveka Frykman","Ziad Hijazi","Mårten Rosenqvist","Johan Engdahl"],"significance":7,"published":"2020-01-01","source_date":"2020-01-01","image":"","kennis":[],"congress":"","summary_en":"The STROKESTOP II study tested a stepwise screening approach using NT-proBNP as a pre-selection tool for AF screening, demonstrating that biomarker-guided selection can improve the efficiency of population-level atrial fibrillation detection.","created":"2026-07-03T10:28:21Z","updated":"2026-07-03T13:27:32Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"STROKESTOP II resultaten van stapsgewijze massascreening op AF met NT-proBNP als voorselectie. Eerste resultaten van dit innovatieve screeningsontwerp.","abstract_original":"AIMS: To study the prevalence of unknown atrial fibrillation (AF) in a high-risk, 75/76-year-old, population using N-terminal B-type natriuretic peptide (NT-proBNP) and handheld electrocardiogram (ECG) recordings in a stepwise screening procedure. METHODS AND RESULTS: The STROKESTOP II study is a population-based cohort study in which all 75/76-year-old in the Stockholm region (n = 28 712) were randomized 1:1 to be invited to an AF screening programme or to serve as the control group. Participants without known AF had NT-proBNP analysed and were stratified into low-risk (NT-proBNP <125 ng/L) and high-risk (NT-proBNP ≥125 ng/L) groups. The high-risk group was offered extended ECG-screening, whereas the low-risk group performed only one single-lead ECG recording. In total, 6868 individuals accepted the screening invitation of which 6315 (91.9%) did not have previously known AF. New AF was detected in 2.6% [95% confidence interval (CI) 2.2-3.0] of all participants without previous AF. In the high-risk group (n = 3766/6315, 59.6%), AF was diagnosed in 4.4% (95% CI 3.7-5.1) of the participants. Out of these, 18% had AF on their index-ECG. In the low-risk group, one participant was diagnosed with AF on index-ECG. The screening procedure resulted in an increase in known prevalence from 8.1% to 10.5% among participants. Oral anticoagulant treatment was initiated in 94.5% of the participants with newly diagnosed AF. CONCLUSION: N-terminal B-type natriuretic peptide-stratified systematic screening for AF identified 4.4% of the high-risk participants with new AF. Oral anticoagulant treatment initiation was well accepted in the group diagnosed with new AF."}