{"id":"b5891c9c4fee","type":"article","url":"https://hartvaat.nl/2020/03/10/kokosolie-en-cardiovasculaire-risicofactoren-meta-analyse-van-klinische-trials/","title":"Kokosolie en cardiovasculaire risicofactoren: meta-analyse van klinische trials","title_en":"The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts"],"tags":["biomarkers-cardiovasculair","colcot-trial","diabetes-en-hart","diabetes-type-2","dyslipidemie","ezetimibe","farmaco-economie","fidelio-dkd","figaro-dkd","hdl-cholesterol","inflammatie","lipide-aferese","lipidenverlaging","lipoproteïne-a","menopauze","microbioom","niet-statine-therapie","obesitas","ouderen","pcsk9-remmers","plaquekarakterisatie","roken","secundaire-preventie","select-trial","slaapapneu","soul-trial","statines","voeding-hart"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.119.043052","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.119.043052","authors":["Nithya Neelakantan","Jowy Yi Hoong Seah","Rob M van Dam"],"significance":6,"published":"2020-03-10","source_date":"2020-03-10","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lp-a-verhoogd/","https://hartvaat.nl/kennis/preventie/levenslang-cardiovasculair-risico/"],"congress":"","summary_en":"This meta-analysis showed that coconut oil consumption raises LDL cholesterol compared with non-tropical vegetable oils, challenging the marketing of coconut oil as a heart-healthy alternative.","created":"2026-07-03T10:28:28Z","updated":"2026-07-03T13:27:38Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Systematische review en meta-analyse die het effect van kokosolieconsumptie op cardiovasculaire risicofactoren onderzocht. LDL-stijging bevestigd.","abstract_original":"BACKGROUND: Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular risk factors compared with other cooking oils using data from clinical trials. METHODS: We searched PubMed, SCOPUS, Cochrane Registry, and Web of Science through June 2019. We selected trials that compared the effects of coconut oil consumption with other fats that lasted at least 2 weeks. Two reviewers independently screened articles, extracted data, and assessed the study quality according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The main outcomes included low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), total cholesterol, triglycerides, measures of body fatness, markers of inflammation, and glycemia. Data were pooled using random-effects meta-analysis. RESULTS: 16 articles were included in the meta-analysis. Results were available from all trials on blood lipids, 8 trials on body weight, 5 trials on percentage body fat, 4 trials on waist circumference, 4 trials on fasting plasma glucose, and 5 trials on C-reactive protein. Coconut oil consumption significantly increased LDL-cholesterol by 10.47 mg/dL (95% CI: 3.01, 17.94; I2 = 84%, N=16) and HDL-cholesterol by 4.00 mg/dL (95% CI: 2.26, 5.73; I2 = 72%, N=16) as compared with nontropical vegetable oils. These effects remained significant after excluding nonrandomized trials, or trials of poor quality (Jadad score <3). Coconut oil consumption did not significantly affect markers of glycemia, inflammation, and adiposity as compared with nontropical vegetable oils. CONCLUSIONS: Coconut oil consumption results in significantly higher LDL-cholesterol than nontropical vegetable oils. This should inform choices about coconut oil consumption."}