{"id":"71ba471bc7d4","type":"article","url":"https://hartvaat.nl/2020/04/14/langetermijnuitkomsten-bij-vrouwen-en-mannen-na-pci/","title":"Langetermijnuitkomsten bij vrouwen en mannen na PCI","title_en":"Long-Term Outcomes in Women and Men Following Percutaneous Coronary Intervention.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2020.01.056","source_url":"https://doi.org/10.1016/j.jacc.2020.01.056","authors":["Ioanna Kosmidou","Martin B Leon","Yiran Zhang","Patrick W Serruys","Clemens von Birgelen","Pieter C Smits","Ori Ben-Yehuda","Björn Redfors","Mahesh V Madhavan","Akiko Maehara","Roxana Mehran","Gregg W Stone"],"significance":5,"published":"2020-04-14","source_date":"2020-04-14","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/"],"congress":"","summary_en":"This analysis of long-term sex differences after PCI showed that women have different risk profiles and complication patterns than men, informing sex-specific post-PCI management approaches.","created":"2026-07-03T10:28:30Z","updated":"2026-07-03T13:27:41Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Analyse van langetermijn-sekseverschillen in uitkomsten na PCI.","abstract_original":"BACKGROUND: Studies examining sex-related outcomes following percutaneous coronary intervention (PCI) have reported conflicting results. OBJECTIVES: The purpose of this study was to examine the sex-related risk of 5-year cardiovascular outcomes after PCI. METHODS: The authors pooled patient-level data from 21 randomized PCI trials and assessed the association between sex and major adverse cardiac events (MACE) (cardiac death, myocardial infarction [MI], or ischemia-driven target lesion revascularization [ID-TLR]) as well as its individual components at 5 years. RESULTS: Among 32,877 patients, 9,141 (27.8%) were women. Women were older and had higher body mass index, more frequent hypertension and diabetes, and less frequent history of surgical or percutaneous revascularization compared with men. By angiographic core laboratory analysis, lesions in women had smaller reference vessel diameter and shorter lesion length. At 5 years, women had a higher unadjusted rate of MACE (18.9% vs. 17.7%; p = 0.003), all-cause death (10.4% vs. 8.7%; p = 0.0008), cardiac death (4.9% vs. 4.0%; p = 0.003) and ID-TLR (10.9% vs. 10.2%; p = 0.02) compared with men. By multivariable analysis, female sex was an independent predictor of MACE (hazard ratio [HR:]: 1.14; 95% confidence interval [CI:]: 1.01 to 1.30; p = 0.04) and ID-TLR (HR: 1.23; 95% CI: 1.05 to 1.44; p = 0.009) but not all-cause death (HR: 0.91; 95% CI: 0.75 to 1.09; p = 0.30) or cardiac death (HR: 0.97; 95% CI: 0.73 to 1.29; p = 0.85). CONCLUSIONS: In the present large-scale, individual patient data pooled analysis of contemporary PCI trials, women had a higher risk of MACE and ID-TLR compared with men at 5 years following PCI."}