# Sekse-specifieke CV-risicofactoren en biomarkers bij incident hartfalen

*geplaatst 2020-09-22 · Hartfalen · Journal of the American College of Cardiology · doi 10.1016/j.jacc.2020.07.044 · https://hartvaat.nl/2020/09/22/sekse-specifieke-cv-risicofactoren-en-biomarkers-bij-incident-hartfalen/*

Studie naar sekse-specifieke associaties van cardiovasculaire risicofactoren en biomarkers met incident hartfalen.

## English: Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure.

This study identified sex-specific associations between cardiovascular risk factors, biomarkers, and incident heart failure, showing that risk factor contributions to HF differ between men and women.

## Abstract (original, from the publication)

BACKGROUND: Whether cardiovascular (CV) disease risk factors and biomarkers associate differentially with heart failure (HF) risk in men and women is unclear. OBJECTIVES: The purpose of this study was to evaluate sex-specific associations of CV risk factors and biomarkers with incident HF. METHODS: The analysis was performed using data from 4 community-based cohorts with 12.5 years of follow-up. Participants (recruited between 1989 and 2002) were free of HF at baseline. Biomarker measurements included natriuretic peptides, cardiac troponins, plasminogen activator inhibitor-1, D-dimer, fibrinogen, C-reactive protein, sST2, galectin-3, cystatin-C, and urinary albumin-to-creatinine ratio. RESULTS: Among 22,756 participants (mean age 60 ± 13 years, 53% women), HF occurred in 2,095 participants (47% women). Age, smoking, type 2 diabetes mellitus, hypertension, body mass index, atrial fibrillation, myocardial infarction, left ventricular hypertrophy, and left bundle branch block were strongly associated with HF in both sexes (p < 0.001), and the combined clinical model had good discrimination in men (C-statistic = 0.80) and in women (C-statistic = 0.83). The majority of biomarkers were strongly and similarly associated with HF in both sexes. The clinical model improved modestly after adding natriuretic peptides in men (ΔC-statistic = 0.006; likelihood ratio chi-square = 146; p < 0.001), and after adding cardiac troponins in women (ΔC-statistic = 0.003; likelihood ratio chi-square = 73; p < 0.001). CONCLUSIONS: CV risk factors are strongly and similarly associated with incident HF in both sexes, highlighting the similar importance of risk factor control in reducing HF risk in the community. There are subtle sex-related differences in the predictive value of individual biomarkers, but the overall improvement in HF risk estimation when included in a clinical HF risk prediction model is limited in both sexes.

Auteurs: Navin Suthahar, Emily S Lau, Michael J Blaha, Samantha M Paniagua, Martin G Larson, Bruce M Psaty, Emelia J Benjamin, Matthew A Allison, Traci M Bartz, James L Januzzi, Daniel Levy, Laura M G Meems, Stephan J L Bakker, Joao A C Lima, Mary Cushman, Douglas S Lee, Thomas J Wang, Christopher R deFilippi, David M Herrington, Matthew Nayor, Ramachandran S Vasan, Julius M Gardin, Jorge R Kizer, Alain G Bertoni, Norrina B Allen, Ron T Gansevoort, Sanjiv J Shah, John S Gottdiener, Jennifer E Ho, Rudolf A de Boer

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Bron: Journal of the American College of Cardiology, https://doi.org/10.1016/j.jacc.2020.07.044. Bijgewerkt 2026-07-03T18:38:48Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.