{"id":"39f19a9621f0","type":"article","url":"https://hartvaat.nl/2020/10/01/ticagrelor-monotherapie-versus-dapt-na-pci-bij-nstemi-subanalyse/","title":"Ticagrelor monotherapie versus DAPT na PCI bij NSTEMI: subanalyse","title_en":"Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS.","category":"algemeen","category_label":"Algemeen","professions":["apotheker","cardioloog"],"tags":[],"journal":"European heart journal","doi":"10.1093/eurheartj/ehaa670","source_url":"https://doi.org/10.1093/eurheartj/ehaa670","authors":["Usman Baber","George Dangas","Dominick Joseph Angiolillo","David Joel Cohen","Samin Kumar Sharma","Johny Nicolas","Carlo Briguori","Jin Yu Cha","Timothy Collier","Dariusz Dudek","Vladimir Džavik","Javier Escaned","Robert Gil","Paul Gurbel","Christian W Hamm","Timothy Henry","Kurt Huber","Adnan Kastrati","Upendra Kaul","Ran Kornowski","Mitchell Krucoff","Vijay Kunadian","Steven Owen Marx","Shamir Mehta","David Moliterno","Erik Magnus Ohman","Keith Oldroyd","Gennaro Sardella","Samantha Sartori","Richard Shlofmitz","Philippe Gabriel Steg","Giora Weisz","Bernhard Witzenbichler","Ya-Ling Han","Stuart Pocock","Charles Michael Gibson","Roxana Mehran"],"significance":6,"published":"2020-10-01","source_date":"2020-10-01","image":"","kennis":["https://hartvaat.nl/kennis/coronairlijden/stemi/","https://hartvaat.nl/kennis/antistolling/doac-versus-vka-keuze/"],"congress":"","summary_en":"This subanalysis of ticagrelor monotherapy versus DAPT specifically in NSTEMI patients after PCI confirmed that aspirin discontinuation reduces bleeding without increasing ischemic events in this acute population.","created":"2026-07-03T10:28:48Z","updated":"2026-07-03T13:27:57Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Subanalyse van ticagrelor monotherapie versus DAPT na PCI specifiek bij NSTEMI-patiënten.","abstract_original":"AIMS: The aim of this study was to determine the effect of ticagrelor monotherapy on clinically relevant bleeding and major ischaemic events in relation to clinical presentation with and without non-ST elevation acute coronary syndromes (NSTE-ACS) among patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). METHODS AND RESULTS: We conducted a pre-specified subgroup analysis of The Ticagrelor With Aspirin or Alone in High Risk Patients After Coronary Intervention (TWILIGHT) trial, which enrolled 9006 patients with high-risk features undergoing PCI with DES. After 3 months of dual antiplatelet therapy (DAPT) with ticagrelor plus aspirin, 7119 adherent and event-free patients were randomized in a double-blind manner to ticagrelor plus placebo versus ticagrelor plus aspirin for 12 months. The primary outcome was Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding while the composite of all-cause death, myocardial infarction (MI), or stroke was the key secondary outcome. Among patients with NSTE-ACS (n = 4614), ticagrelor monotherapy reduced BARC 2, 3, or 5 bleeding by 53% [3.6% vs. 7.6%; hazard ratio (HR) 0.47; 95% confidence interval (CI) 0.36-0.61; P < 0.001) and in stable patients (n = 2503) by 24% (4.8% vs. 6.2%; HR 0.76; 95% CI 0.54-1.06; P = 0.11; nominal Pint = 0.03). Rates of all-cause death, MI, or stroke among those with (4.3% vs. 4.4%; HR 0.97; 95% CI 0.74-1.28; P = 0.84) and without (3.1% vs. 3.2%; HR 0.96; 95% CI 0.61-1.49; P = 0.85) NSTE-ACS were similar between treatment arms irrespective of clinical presentation (Pint = 0.96). CONCLUSION: Among patients with or without NSTE-ACS who have completed an initial 3-month course of DAPT following PCI with DES, ticagrelor monotherapy reduced clinically meaningful bleeding events without increasing ischaemic risk as compared with ticagrelor plus aspirin. The benefits of ticagrelor monotherapy with respect to bleeding events were more pronounced in patients with NSTE-ACS. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT02270242."}