# Postoperatief AF en langetermijn CVA-risico na geïsoleerde CABG

*geplaatst 2020-10-06 · Atriumfibrilleren · Circulation · doi 10.1161/CIRCULATIONAHA.120.046940 · https://hartvaat.nl/2020/10/06/postoperatief-af-en-langetermijn-cva-risico-na-geisoleerde-cabg/*

Studie naar postoperatief AF en het langetermijn risico op beroerte na geïsoleerde coronaire bypasschirurgie.

## English: Postoperative Atrial Fibrillation and Long-Term Risk of Stroke After Isolated Coronary Artery Bypass Graft Surgery.

This study demonstrated that postoperative atrial fibrillation after isolated CABG is associated with significantly increased long-term stroke risk, supporting consideration of anticoagulation in patients who develop AF after cardiac surgery.

## Abstract (original, from the publication)

BACKGROUND: Postoperative atrial fibrillation (pAF) after coronary artery bypass grafting is a common complication. Whether pAF is associated with an increased risk of cerebrovascular accident (CVA) remains uncertain. We investigated the association between pAF and long-term risk of CVA by performing a post hoc analysis of 10-year outcomes of the ART (Arterial Revascularization Trial). METHODS: For the present analysis, among patients enrolled in the ART (n=3102), we excluded those who did not undergo surgery (n=25), had a history of atrial fibrillation (n=45), or had no information on the incidence of pAF (n=9). The final population consisted of 3023 patients, of whom 734 (24.3%) developed pAF with the remaining 2289 maintaining sinus rhythm. Competing risk and Cox regression analyses were used to investigate the association between pAF and the risk of CVA. RESULTS: At 10 years, the cumulative incidence of CVA was 6.3% (4.6%-8.1%) versus 3.7% (2.9%-4.5%) in patients with pAF and sinus rhythm, respectively. pAF was an independent predictor of CVA at 10 years (hazard ratio, 1.53 [95% CI, 1.06-2.23]; P=0.025) even when CVAs that occurred during the index admission were excluded from the analysis (hazard ratio, 1.47 [95% 1.02-2.11]; P=0.04). CONCLUSIONS: Patients with pAF after coronary artery bypass grafting are at higher risk of CVA. These findings challenge the notion that pAF is a benign complication.

Auteurs: Umberto Benedetto, Mario F Gaudino, Arnaldo Dimagli, Stephen Gerry, Alastair Gray, Belinda Lees, Marcus Flather, David P Taggart

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Bron: Circulation, https://doi.org/10.1161/CIRCULATIONAHA.120.046940. Bijgewerkt 2026-07-03T13:27:58Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.