# Chinese kruidenformule voor gemaskeerde hypertensie: gerandomiseerde placebogecontroleerde trial

*geplaatst 2020-11-10 · Hypertensie · Circulation · doi 10.1161/CIRCULATIONAHA.120.046685 · https://hartvaat.nl/2020/11/10/chinese-kruidenformule-voor-gemaskeerde-hypertensie-gerandomiseerde-placebogecon/*

Gerandomiseerde placebogecontroleerde trial naar een Chinese kruidenformule voor behandeling van gemaskeerde hypertensie.

## English: Treatment of Masked Hypertension with a Chinese Herbal Formula: A Randomized, Placebo-Controlled Trial.

This randomized placebo-controlled trial tested a Chinese herbal formula for treating masked hypertension, providing the first controlled evidence for traditional herbal medicine in this specific blood pressure phenotype.

## Abstract (original, from the publication)

BACKGROUND: Masked hypertension is associated with adverse cardiovascular outcomes. Nonetheless, no randomized controlled trials exist in the treatment of masked hypertension. The aim of this randomized, placebo-controlled trial was to investigate the efficacy and safety of blood pressure (BP)-lowering treatment with a Chinese herbal formula, gastrodia-uncaria granules, in patients with masked hypertension. METHODS: Patients with an office BP of <140/90 mm Hg and daytime ambulatory BP of 135 to 150 mm Hg systolic or 85 to 95 mm Hg diastolic were randomly assigned 1:1 to the treatment of gastrodia-uncaria granules or placebo 5 to 10 g twice daily for 4 weeks. The primary efficacy variable was the change in daytime ambulatory BP. RESULTS: At baseline, office and daytime BP of the 251 participants (mean age, 50.4 years; 53.4% men; mean body mass index 24.5 kg/m2; and 2.8%, 1.6%, and 30.7% with cardiovascular disease, diabetes, and smoking, respectively) averaged 129/82 and 135/89 mm Hg, respectively. In the intention-to-treat analysis, daytime systolic/diastolic BP was reduced by 5.44/3.39 and 2.91/1.60 mm Hg in the gastrodia-uncaria granules and placebo groups, respectively. The between-group difference in BP reductions was significant for the daytime (2.52/1.79 mm Hg; P≤0.025) and 24-hour BP (2.33/1.49 mm Hg; P≤0.012), but not for the clinic and nighttime BPs (P≥0.162). The per-protocol analysis in 229 patients produced similar results. Only 1 adverse event (sleepiness during the day) was reported, and no serious adverse event occurred. CONCLUSIONS: BP-lowering treatment with Chinese traditional medicine gastrodia-uncaria granules is efficacious for patients with masked hypertension. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02156024.

Auteurs: Dong-Yan Zhang, Yi-Bang Cheng, Qian-Hui Guo, Xiao-Li Shan, Fang-Fei Wei, Feng Lu, Chang-Sheng Sheng, Qi-Fang Huang, Chuan-Hua Yang, Yan Li, Ji-Guang Wang

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Bron: Circulation, https://doi.org/10.1161/CIRCULATIONAHA.120.046685. Bijgewerkt 2026-07-03T18:38:48Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.