{"id":"870230553ead","type":"article","url":"https://hartvaat.nl/2020/11/26/n-of-1-trial-van-statine-placebo-of-geen-behandeling-voor-bijwerkingen-nejm-stat/","title":"N-of-1 trial van statine, placebo of geen behandeling voor bijwerkingen: NEJM StatinWISE","title_en":"N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects.","category":"cholesterol","category_label":"Cholesterol","professions":["apotheker","cardioloog","huisarts","internist"],"tags":["clear-outcomes","niet-statine-therapie","rosuvastatine","statines"],"journal":"The New England journal of medicine","doi":"10.1056/NEJMc2031173","source_url":"https://doi.org/10.1056/NEJMc2031173","authors":["Frances A Wood","James P Howard","Judith A Finegold","Alexandra N Nowbar","David M Thompson","Ahran D Arnold","Christopher A Rajkumar","Susan Connolly","Jaimini Cegla","Chris Stride","Peter Sever","Christine Norton","Simon A M Thom","Matthew J Shun-Shin","Darrel P Francis"],"significance":10,"published":"2020-11-26","source_date":"2020-11-26","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/ezetimib/","https://hartvaat.nl/kennis/farmacologie/colchicine-cardiovasculair/"],"congress":"","summary_en":"The StatinWISE N-of-1 trial demonstrated that muscle symptoms attributed to statins were largely not reproducible under blinded conditions, with similar symptom scores during statin and placebo periods. This provided rigorous evidence that most statin-associated side effects are attributable to the nocebo effect rather than the drug itself.","created":"2026-07-03T10:28:55Z","updated":"2026-07-03T13:28:04Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"NEJM StatinWISE N-of-1 trial die aantoonde dat statinebijwerkingen grotendeels niet reproduceerbaar zijn in geblindeerde rechallenge. Definitief nocebo-bewijs.","abstract_original":""}