{"id":"0775dfe05825","type":"article","url":"https://hartvaat.nl/2021/06/14/gestandaardiseerde-inspanningstraining-bij-pah-en-cteph-haalbaarheid-en-veilighe/","title":"Gestandaardiseerde inspanningstraining bij PAH en CTEPH: haalbaarheid en veiligheid","title_en":"Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog"],"tags":[],"journal":"European heart journal","doi":"10.1093/eurheartj/ehaa696","source_url":"https://doi.org/10.1093/eurheartj/ehaa696","authors":["Ekkehard Grünig","Alison MacKenzie","Andrew J Peacock","Christina A Eichstaedt","Nicola Benjamin","Robert Nechwatal","Silvia Ulrich","Stéphanie Saxer","Maurizio Bussotti","Marinella Sommaruga","Stefano Ghio","Lina Gumbiene","Eglė Palevičiūtė","Elena Jurevičienė","Antonio Cittadini","Anna A Stanziola","Alberto M Marra","Gabor Kovacs","Horst Olschewski","Joan-Albert Barberà","Isabel Blanco","Martijn A Spruit","Frits M E Franssen","Anton Vonk Noordegraaf","Abílio Reis","Mário Santos","Sofia Gonçalves Viamonte","Heleen Demeyer","Marion Delcroix","Eduardo Bossone","Martin Johnson"],"significance":6,"published":"2021-06-14","source_date":"2021-06-14","image":"","kennis":[],"congress":"","summary_en":"This multicenter randomized trial confirmed that standardized exercise training is feasible, safe, and effective in patients with PAH and CTEPH, supporting supervised rehabilitation as standard of care in pulmonary hypertension management.","created":"2026-07-03T10:29:14Z","updated":"2026-07-03T13:28:23Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Studie die aantoont dat gestandaardiseerde inspanningstraining haalbaar, veilig en effectief is bij PAH en CTEPH.","abstract_original":"AIMS: This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS: For the first time a specialized PAH/CTEPH rehabilitation programme was implemented in 11 centres across 10 European countries. Out of 129 enrolled patients, 116 patients (58 vs. 58 randomized into a training or usual care control group) on disease-targeted medication completed the study [85 female; mean age 53.6 ± 12.5 years; mean pulmonary arterial pressure 46.6 ± 15.1 mmHg; World Health Organization (WHO) functional class II 53%, III 46%; PAH n = 98; CTEPH n = 18]. Patients of the training group performed a standardized in-hospital rehabilitation with mean duration of 25 days [95% confidence interval (CI) 17-33 days], which was continued at home. The primary endpoint, change of 6-min walking distance, significantly improved by 34.1 ± 8.3 m in the training compared with the control group (95% CI, 18-51 m; P < 0.0001). Exercise training was feasible, safe, and well-tolerated. Secondary endpoints showed improvements in quality of life (short-form health survey 36 mental health 7.3 ± 2.5, P = 0.004), WHO-functional class (training vs. control: improvement 9:1, worsening 4:3; χ2P = 0.027) and peak oxygen consumption (0.9 ± 0.5 mL/min/kg, P = 0.048) compared with the control group. CONCLUSION: This is the first multicentre and so far the largest randomized, controlled study on feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH. Within this study, a standardized specialized training programme with in-hospital start was successfully established in 10 European countries."}