# Hogere intraoperatieve bloeddrukstreefwaarden en CV-events bij niet-cardiale chirurgie

*geplaatst 2021-11-02 · Hartfalen · Journal of the American College of Cardiology · doi 10.1016/j.jacc.2021.08.048 · https://hartvaat.nl/2021/11/02/hogere-intraoperatieve-bloeddrukstreefwaarden-en-cv-events-bij-niet-cardiale-chi/*

Studie die aantoont dat het nastreven van hogere intraoperatieve bloeddrukken geen CV-events vermindert na niet-cardiale chirurgie.

## English: Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery.

This study showed that targeting higher intraoperative blood pressures during non-cardiac surgery does not reduce postoperative cardiovascular events, challenging the strategy of aggressive intraoperative hemodynamic augmentation.

## Abstract (original, from the publication)

BACKGROUND: Intraoperative arterial hypotension is strongly associated with postoperative major adverse cardiovascular events (MACE); however, whether targeting higher intraoperative mean arterial blood pressures (MAPs) may prevent adverse events remains unclear. OBJECTIVES: This study sought to determine whether targeting higher intraoperative MAP lowers the incidence of postoperative MACE. METHODS: This single-center randomized controlled trial assigned adult patients at cardiovascular risk undergoing major noncardiac surgery to an intraoperative MAP target of ≥60 mm Hg (control) or ≥75 mm Hg (MAP ≥75). The primary outcome was acute myocardial injury on postoperative days 0-3 and/or 30-day MACE/acute kidney injury (AKI) (acute coronary syndrome, congestive heart failure, coronary revascularization, stroke, AKI, and all-cause mortality). The secondary outcome was 1-year MACE. RESULTS: In total, 458 patients were randomized (intention-to-treat population: 451). The cumulative intraoperative duration with MAP <65 mm Hg was significantly shorter in the MAP ≥75 group (median 9 minutes [interquartile range: 3 to 24 minutes] vs 23 minutes [interquartile range: 8-49 minutes]; P < 0.001). The primary outcome incidence was 48% for MAP ≥75 and 52% for control (risk difference -4.2%; 95% CI: -13% to +5%), the primary contributor being AKI (incidence 44%). Acute myocardial injury occurred in 15% (MAP ≥75) and 19% (control) of patients. The secondary outcome incidence was 17% for MAP ≥75 and 15% for control (risk difference +2.7; 95% CI: -4% to +9.5%). CONCLUSIONS: These findings do not support universally targeting higher intraoperative blood pressures to reduce postoperative complications. Despite a 60% reduction in hypotensive time with MAP <65 mm Hg, no significant reductions in acute myocardial injury or 30-day MACE/AKI could be found. (Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery [BBB]; NCT02533128).

Auteurs: Patrick M Wanner, Dirk U Wulff, Mirjana Djurdjevic, Wolfgang Korte, Thomas W Schnider, Miodrag Filipovic

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Bron: Journal of the American College of Cardiology, https://doi.org/10.1016/j.jacc.2021.08.048. Bijgewerkt 2026-07-03T13:28:36Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.