{"id":"ce97d29cc13b","type":"article","url":"https://hartvaat.nl/2021/11/14/regionale-en-etnische-invloeden-op-empagliflozine-bij-hfref-emperor-reduced/","title":"Regionale en etnische invloeden op empagliflozine bij HFrEF: EMPEROR-Reduced","title_en":"Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":["emperor-trials","hfref"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehab360","source_url":"https://doi.org/10.1093/eurheartj/ehab360","authors":["Carolyn S P Lam","João Pedro Ferreira","Egon Pfarr","David Sim","Hiroyuki Tsutsui","Stefan D Anker","Javed Butler","Gerasimos Filippatos","Stuart J Pocock","Naveed Sattar","Subodh Verma","Martina Brueckmann","Janet Schnee","Daniel Cotton","Faiez Zannad","Milton Packer"],"significance":5,"published":"2021-11-14","source_date":"2021-11-14","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/sglt2-remmers-bij-hartfalen/"],"congress":"","summary_en":"This EMPEROR-Reduced analysis showed that empagliflozin's benefit in HFrEF is consistent across geographic regions and racial/ethnic groups, supporting universal SGLT2 inhibitor use regardless of population background.","created":"2026-07-03T10:29:30Z","updated":"2026-07-03T13:28:37Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"EMPEROR-Reduced analyse naar regionale en etnische invloeden op de respons op empagliflozine bij HFrEF.","abstract_original":"AIMS: The aim of this article is to explore the influence of region and race/ethnicity on the effects of empagliflozin in the Empagliflozin Outcome Trial in Patients with Chronic Heart Failure and a Reduced Ejection Fraction (EMPEROR-Reduced) trial. METHODS AND RESULTS: Of 3730 patients, 1353 (36.3%) were enrolled in Europe, 1286 (34.5%) in Latin America, 425 (11.4%) in North America, and 493 (13.2%) in Asia; 2629 (70.5%) were White, 257 (6.9%) Black, and 672 (18.0%) Asian. Placebo event rates (per 100 patient-years) for cardiovascular death or heart failure (HF) hospitalization varied by region (Asia 27.7, North America 26.4, Latin America 21.4, and Europe 17.5) and race/ethnicity (Black 34.4, Asian 24.3, and White 18.7); driven by differences in HF hospitalization. The ratio of total HF hospitalization to cardiovascular death varied from 5.4 in Asia and 4.8 in North America to 2.1 in Europe; and from 4.8 in Black and 4.2 in Asian to 2.2 in White patients. Groups with the highest ratio had the greatest reduction in the primary outcome with empagliflozin. Inclusion of outpatient worsening HF episodes added more events in Europe vs. other regions; enhanced the placebo event rates in Europe vs. other regions; and increased the relative risk reduction with empagliflozin in Europe from 6% to 26%. CONCLUSIONS: There were notable differences in the placebo event rates for major HF events across diverse regions and race/ethnic groups. The benefit of empagliflozin was most pronounced in groups with the highest ratio of HF hospitalization to cardiovascular death. Regional differences were attenuated when the definition of HF events was expanded to include outpatient worsening HF events."}