{"id":"0b035797813d","type":"article","url":"https://hartvaat.nl/2021/12/01/lv-dimensies-en-cv-uitkomsten-bij-systolisch-hf-warcef/","title":"LV-dimensies en CV-uitkomsten bij systolisch HF: WARCEF","title_en":"Left ventricular dimensions and cardiovascular outcomes in systolic heart failure: the WARCEF trial.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":[],"journal":"ESC heart failure","doi":"10.1002/ehf2.13560","source_url":"https://doi.org/10.1002/ehf2.13560","authors":["Kazato Ito","Siyuan Li","Shunichi Homma","John L P Thompson","Richard Buchsbaum","Kenji Matsumoto","Stefan D Anker","Min Qian","Marco R Di Tullio"],"significance":5,"published":"2021-12-01","source_date":"2021-12-01","image":"","kennis":[],"congress":"","summary_en":"This WARCEF analysis showed that LV dimensions are independently associated with cardiovascular outcomes in systolic heart failure, supporting echocardiographic size parameters for risk stratification beyond ejection fraction.","created":"2026-07-03T10:29:31Z","updated":"2026-07-03T13:28:38Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"WARCEF analyse naar LV-dimensies en cardiovasculaire uitkomsten bij systolisch hartfalen.","abstract_original":"AIMS: There is limited information on the association between left ventricular (LV) dimensions and cardiovascular (CV) outcomes in patients with heart failure (HF) with reduced LV ejection fraction (HFrEF) receiving recommended HF treatment. We investigated the association between LV dimensions and CV outcomes in HFrEF patients receiving recommended HF treatment. METHODS AND RESULTS: We investigated the association between LV echocardiographic dimensions and CV outcomes using conventional Cox models in 1138 HFrEF patients in sinus rhythm randomized to warfarin or aspirin treatment in the Warfarin vs. Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) trial. LV enlargement, whether by diameter [LV end-diastolic diameter index (LVEDDI) and LV end-systolic diameter index (LVESDI)] or volume [LV end-diastolic volume index (LVEDVI) and LV end-systolic volume index (LVESVI)], was independently associated with all-cause death [LVEDDI: hazard ratio (HR) per cm/m2 1.53, LVESDI: HR per cm/m2 1.65, LVEDVI: HR per 10 mL/m2 1.07, and LVESVI: HR per 10 mL/m2 1.10; all P values < 0.001], CV death (HR 1.68, 1.79, 1.09, and 1.12, respectively; all P values < 0.001), and HF hospitalization (HR 1.59, 1.79, 1.06, and 1.08, respectively; all P values < 0.001). No association was observed with myocardial infarction or stroke. The associations were independent of LV ejection fraction values, and incremental to them. LV volumes conferred additional predictive value over LV diameters. CONCLUSIONS: Left ventricular enlargement is an independent predictor of CV events in patients with HFrEF and recommended HF treatment. LV dimensions should be considered in the risk assessment."}