{"id":"0d236ebd0c30","type":"article","url":"https://hartvaat.nl/2022/06/01/finger-trial-multidomein-leefstijlinterventie-verlaagt-cardiovasculair-risico-bi/","title":"FINGER-trial: multidomein-leefstijlinterventie verlaagt cardiovasculair risico bij ouderen","title_en":"Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.","category":"preventie","category_label":"Preventie","professions":["cardioloog","huisarts","internist"],"tags":["atleten","hartrevalidatie","lichaamsbeweging","stride-trial","summit-trial"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehab922","source_url":"https://doi.org/10.1093/eurheartj/ehab922","authors":["Jenni Lehtisalo","Minna Rusanen","Alina Solomon","Riitta Antikainen","Tiina Laatikainen","Markku Peltonen","Timo Strandberg","Jaakko Tuomilehto","Hilkka Soininen","Miia Kivipelto","Tiia Ngandu"],"significance":7,"published":"2022-06-01","source_date":"2022-06-01","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/ezetimib/","https://hartvaat.nl/kennis/lipiden/lipidenmedicatie-bij-ckd/"],"congress":"","summary_en":"The FINGER trial, originally designed for cognitive outcomes, also demonstrated cardiovascular risk reduction from a multi-domain lifestyle intervention (diet, exercise, cognitive training, vascular risk management) in older adults at risk for dementia.","created":"2026-07-03T10:29:47Z","updated":"2026-07-03T13:28:54Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De FINGER-trial, oorspronkelijk gericht op cognitieve achteruitgang, toonde ook een gunstig effect van multidomein-leefstijlinterventie op cardiovasculair risico bij ouderen. De interventie combineerde voeding, beweging, cognitieve training en vaatrisicomanagement met succes.","abstract_original":"AIMS: Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome). METHODS AND RESULTS: FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials.gov NCT01041989). They were randomized (1:1) to a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). National registries provided data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event. During an average of 7.4 years, 229 participants (18%) had at least one CVD diagnosis: 107 in the intervention group and 122 in the control group. The incidence of cerebrovascular events was lower in the intervention than the control group: hazard ratio (HR) for combined stroke/TIA was 0.71 [95% confidence interval (CI): 0.51-0.99] after adjusting for background characteristics. Hazard ratio for coronary events was 0.84 (CI: 0.56-1.26) and total CVD events 0.80 (95% CI: 0.61-1.04). Among those with history of CVD (n = 145), the incidence of both total CVD events (HR: 0.50, 95% CI: 0.28-0.90) and stroke/TIA (HR: 0.40, 95% CI: 0.20-0.81) was lower in the intervention than the control group. CONCLUSION: A 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD."}