{"id":"c18246e9bff7","type":"article","url":"https://hartvaat.nl/2022/06/01/interatriale-shuntdevices-bij-hartfalen-systematische-review-en-meta-analyse/","title":"Interatriale shuntdevices bij hartfalen: systematische review en meta-analyse","title_en":"Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta-analysis.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":["hfmref","hfpef","hfref","ventrikelfibrilleren","vericiguat"],"journal":"ESC heart failure","doi":"10.1002/ehf2.13911","source_url":"https://doi.org/10.1002/ehf2.13911","authors":["Tieci Yi","Min Li","Fangfang Fan","Lin Qiu","Zhi Wang","Haoyu Weng","Xiaoke Shang","Changdong Zhang","Wei Ma","Yan Zhang","Yong Huo"],"significance":6,"published":"2022-06-01","source_date":"2022-06-01","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/palliatief-hartfalen/","https://hartvaat.nl/kennis/diagnostiek/transthoracale-echocardiografie/"],"congress":"","summary_en":"This meta-analysis of interatrial shunt devices for heart failure showed significant reductions in pulmonary wedge pressure and improvements in hemodynamic parameters, though clinical outcomes trials subsequently yielded mixed results.","created":"2026-07-03T10:29:46Z","updated":"2026-07-03T18:38:52Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Meta-analyse van interatriale shuntdevices bij hartfalen toonde significante daling van wiggendruk en linkerventriculaire einddiastolische druk. Echter, de klinische voordelen bleven onbewezen en het risico op device-gerelateerde complicaties beperkt de toepassing vooralsnog.","abstract_original":"AIMS: To assess the efficacy and safety, primarily in relation to the haemodynamic effects, of interatrial shunting devices (ISD) for the treatment of heart failure (HF), we conducted a systematic review and a meta-analysis. METHODS AND RESULTS: We used the MEDLINE, Cochrane Library, Embase, and PubMed databases to identify clinical studies (published to 4 August 2021) that evaluated the effect of ISD on HF. The primary endpoint was defined as changes in pulmonary capillary wedge pressure (PCWP). Secondary endpoints included (i) other haemodynamic indexes, including cardiac output (CO), right atrial pressure (RAP), and mean pulmonary artery pressure (mPAP) by right heart catheterization, and (ii) change from baseline in 6 min walk distance (6MWD). After a literature search and detailed evaluation, six trials enrolling a total of 203 individuals were included in the quantitative analysis. Pooled analyses showed that after ISD implantation, PCWP decreased by a mean 3.10 mmHg [95% confidence interval (CI) -4.56 to -1.64; I2  = 0%; P < 0.0001]. Overall, CO increased by 0.77 L/min (95% CI 0.02 to 1.52; P = 0.04; I2  = 82%), but there were no significant changes in RAP or mPAP. The mean 6MWD increased by 32.33 m (95% CI 10.74 to 53.92; P = 0.003; I2  = 0) after ISD implantation. CONCLUSIONS: Interatrial shunting device can effectively reduce PCWP, increase CO and 6MWD, and has no obvious adverse effects on the right heart and pulmonary pressure. Studies with larger sample size and longer follow-up time are needed for further verification."}